Hydromorphinol

Base Information

• Chemical Name: Hydromorphinol
• CAS No.: 2183-56-4
• Molecular Formula: C17H21 N O4
• Molecular Weight: 303.358
• Hs Code.: 2939190022
• European Community (EC) Number: 218-565-9
• UNII: 1O00P9X5C1
• DSSTox Substance ID: DTXSID30176242
• Nikkaji Number: J7.353I
• Wikipedia: Hydromorphinol,Oxymorphol
• Wikidata: Q5955182
• NCI Thesaurus Code: C91043
• Metabolomics Workbench ID: 146162
• ChEMBL ID: CHEMBL1951706
• Mol file: 2183-56-4.mol

Synonyms:HYDROMORPHINOL;2183-56-4;6alpha-Oxymorphol;14-Hydroxydihydromorphine;Numorphan Oral;.alpha.-oxymorphol;6.alpha.-Oxymorphol;Idromorfinolo [DCIT];14-Hydroxy-7,8-dihydromorphine;7,8-Dihydro-14-hydroxymorphine;14-Hydroxy-dihydromorphin;Hidromorfinol [INN-Spanish];Hydromorphinolum [INN-Latin];IDS-NH-003;DEA No. 9301;Hydromorphinol [INN:BAN:DCF];RAM-320;1O00P9X5C1;EINECS 218-565-9;Morphine, 7,8-dihydro-14-hydroxy-;BRN 0624918;4,5alpha-Epoxy-17-methyl-3,6alpha,14-morphinantriol;Morphinan-3,6-alpha,14-triol, 4,5-alpha-epoxy-17-methyl-;(4R,4aS,7S,7aR,12bS)-3-methyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,7,9-triol;Hidromorfinol;Idromorfinolo;Oxymorphol;Hydromorphinolum;HYDROMORPHINOL [INN];SCHEMBL161209;UNII-1O00P9X5C1;CHEMBL1951706;Morphinan-3,6,14-triol, 4,5-epoxy-17-methyl-, (5.alpha.,6.alpha.)-;DTXSID30176242;AKOS030241201;DB01512;LS-92176;Q5955182

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Hydromorphinol

Chemical Property:

• Vapor Pressure: 1.53E-11mmHg at 25°C
• Melting Point: 252-253 °C(Solv: ethyl acetate (141-78-6))
• Boiling Point: 517.6°Cat760mmHg
• PKA: 9.39±0.60(Predicted)
• Flash Point: 266.8°C
• PSA: 73.16000
• Density: 1.5g/cm³
• LogP: 0.47490
• XLogP3: -1.1
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 0
• Exact Mass: 303.14705815
• Heavy Atom Count: 22
• Complexity: 501

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCC23C4C(CCC2(C1CC5=C3C(=C(C=C5)O)O4)O)O
• Isomeric SMILES: CN1CC[C@]23[C@@H]4[C@H](CC[C@]2([C@H]1CC5=C3C(=C(C=C5)O)O4)O)O
• Description: 6α-Oxymorphol (CRM) (Item No. 25940) is a certified reference material categorized as an opioid. It is a metabolite of oxymorphone (Item Nos. 15911 | ISO60171). 6α-Oxymorphol is regulated as a Schedule I compound in the United States. This product is intended for research and forensic applications.
• Uses: A metabolite of Oxymorphone

Technology Process of Hydromorphinol

There total 7 articles about Hydromorphinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

oxymorphone (76-41-5) → alpha-Oxymorphol (2183-56-4,483981-19-7)

Guidance literature:

With formic acid; triethylamine; In acetonitrile; at 20 ℃; for 24h; Product distribution / selectivity;

Reference yield: 92.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + noroxymorphone (33522-95-1) → alpha-Oxymorphol (2183-56-4,483981-19-7)

Guidance literature:

formaldehyd; noroxymorphone; In acetonitrile; at 20 ℃; for 16h;

With formic acid; triethylamine; In acetonitrile; at 20 ℃; for 24.5h; Product distribution / selectivity;

Reference yield: 67.0%

14-hydroxydihydrocodeine (7183-69-9) → alpha-Oxymorphol (2183-56-4,483981-19-7)

Guidance literature:

With boron tribromide; In methanol; chloroform;

upstream raw materials:

14-hydroxycodeine

14-hydroxydihydrocodeine

oxymorphone

formaldehyd

Downstream raw materials:

6β-oxymorphamine