Oxymorphone

Base Information Edit

Chemical Name:Oxymorphone
CAS No.:76-41-5
Molecular Formula:C17H19NO4
Molecular Weight:301.342
Hs Code.:2939110000
European Community (EC) Number:200-959-7
NSC Number:19045
UNII:9VXA968E0C
DSSTox Substance ID:DTXSID5023409
Nikkaji Number:J4.174B
Wikipedia:Oxymorphone
Wikidata:Q423380
NCI Thesaurus Code:C29314
RXCUI:7814
Pharos Ligand ID:WVFU6YYB7SXN
Metabolomics Workbench ID:43408
ChEMBL ID:CHEMBL963
Mol file:76-41-5.mol

Synonyms:Numorphan;Opana;Oxymorphone;oxymorphone HCl;Oxymorphone Hydrochloride

This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Oxymorphone Edit

Chemical Property:

Appearance/Colour:Crystalline Solid
Melting Point:248-249 °C
Boiling Point:518.627 °C at 760 mmHg
PKA:pKa 8.50 (Uncertain);9.33 (Uncertain)
Flash Point:267.456 °C
PSA：70.00000
Density:1.503 g/cm³
LogP:0.68310
Storage Temp.:Controlled Substance, -20°C Freezer
XLogP3:0.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:0
Exact Mass:301.13140809
Heavy Atom Count:22
Complexity:539

Purity/Quality:

Safty Information:

Pictogram(s): F,T,T+
Hazard Codes:F,T,T+
Statements: 11-23/24/25-39/23/24/25-26/27/28
Safety Statements: 16-36/37-45-36/37/39-22

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CN1CCC23C4C(=O)CCC2(C1CC5=C3C(=C(C=C5)O)O4)O
Isomeric SMILES:CN1CC[C@]23[C@@H]4C(=O)CC[C@]2([C@H]1CC5=C3C(=C(C=C5)O)O4)O
Recent ClinicalTrials:Levorphanol as a Second Line Opioid in Reducing Pain in Patients With Cancer
Biological Functions Oxymorphone is 10 times as potent as morphine, with actions similar to those of hydromorphone. Oxymorphone, however, has little antitussive activity, and as such is a useful analgesic in patients with pulmonary disease who need to retain the ability to cough.

Technology Process of Oxymorphone

There total 32 articles about Oxymorphone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.8%

: 357-07-3
oxymorphone hydrochloride

: 76-41-5
oxymorphone

Guidance literature:: With sodium hydroxide; In water; butan-1-ol; at 20 - 50 ℃; for 1h; pH=8.16;

Reference yield: 95.0%

: 76-42-6
Oxycodone

: 76-41-5
oxymorphone

Guidance literature:: Oxycodone; With tetra-(n-butyl)ammonium iodide; In dichloromethane; at 25 - 30 ℃; for 0.25h; Inert atmosphere;

With boron dimethyl-trifluoro sulphide; In dichloromethane; at 0 - 30 ℃; for 16h; Solvent; Reagent/catalyst; Inert atmosphere;