Erlotinib Impurity 20

Base Information Edit

Chemical Name:Erlotinib Impurity 20
CAS No.:236750-62-2
Molecular Formula:C13H20N2O5
Molecular Weight:284.312
Hs Code.:
Mol file:236750-62-2.mol

Synonyms:2-amino-4,5-bis(2-methoxyethoxy)benzamide;

Suppliers and Price of Erlotinib Impurity 20

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of Erlotinib Impurity 20 Edit

Chemical Property:

Boiling Point:408.3±45.0 °C(Predicted)
PKA:15.77±0.50(Predicted)
PSA：106.03000
Density:1.198±0.06 g/cm3(Predicted)
LogP:1.69960

Purity/Quality:: NLT 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 2-Amino-4,5-bis(2-methoxyethoxy)benzamide is an impurity of Erlotinib (E625008), a EGFR-targeted drug in the treatment of non-small cell lung cancer. EGFR small tyrosine kinase inhibitor that shows most substantial effect on tumor growth inhibition and animal survival.

Technology Process of Erlotinib Impurity 20

There total 5 articles about Erlotinib Impurity 20 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 236750-65-5
4,5-bis(2-methoxyethoxy)-2-nitrobenzonitrile

: 236750-62-2
2-amino-4,5-bis[(2-methoxy)ethoxy]benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; sodium hydroxide; dihydrogen peroxide / ethanol; water / 0 - 20 °C

2: palladium on activated charcoal; ammonium formate / ethanol / 2 h / Reflux

With palladium on activated charcoal; dihydrogen peroxide; ammonium formate; potassium carbonate; sodium hydroxide; In ethanol; water;

Reference yield:

: 1172625-04-5
4,5-bis(2-methoxyethoxy)-2-nitrobenzamide

: 236750-62-2
2-amino-4,5-bis[(2-methoxy)ethoxy]benzamide

Guidance literature:: With palladium on activated charcoal; ammonium formate; In ethanol; for 2h; Reflux;

Reference yield:

: 80407-68-7
3,4-bis(2-methoxyethoxy)-benzonitrile

: 236750-62-2
2-amino-4,5-bis[(2-methoxy)ethoxy]benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: nitric acid / 48 h / 20 - 50 °C

2: potassium carbonate; sodium hydroxide; dihydrogen peroxide / ethanol; water / 0 - 20 °C

3: palladium on activated charcoal; ammonium formate / ethanol / 2 h / Reflux

With palladium on activated charcoal; dihydrogen peroxide; nitric acid; ammonium formate; potassium carbonate; sodium hydroxide; In ethanol; water;