4,5-Bis(2-Methoxyethoxy)-2-nitrobenzaMide

Base Information

• Chemical Name: 4,5-Bis(2-Methoxyethoxy)-2-nitrobenzaMide
• CAS No.: 1172625-04-5
• Molecular Formula: C13H18N2O7
• Molecular Weight: 314.295
• Hs Code.: 2924299090
• Mol file: 1172625-04-5.mol

Synonyms:4,5-bis(2-Methoxyethoxy)-2-nitrobenzaMide

Chemical Property of 4,5-Bis(2-Methoxyethoxy)-2-nitrobenzaMide

Chemical Property:

• Boiling Point: 439.9±45.0 °C(Predicted)
• PKA: 15.09±0.50(Predicted)
• PSA: 126.82000
• Density: 1.273±0.06 g/cm3(Predicted)
• LogP: 2.15150
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

4,5-Bis(2-methoxyethoxy)-2-nitrobenzamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,5-Bis(2-Methoxyethoxy)-2-nitrobenzaMide

There total 4 articles about 4,5-Bis(2-Methoxyethoxy)-2-nitrobenzaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,5-bis(2-methoxyethoxy)-2-nitrobenzonitrile (236750-65-5) → 4,5-bis(2-methoxyethoxy)-2-nitrobenzamide (1172625-04-5)

Guidance literature:

With dihydrogen peroxide; potassium carbonate; sodium hydroxide; In ethanol; water; at 0 - 20 ℃;

Reference yield:

3,4-bis(2-methoxyethoxy)-benzonitrile (80407-68-7) → 4,5-bis(2-methoxyethoxy)-2-nitrobenzamide (1172625-04-5)

Guidance literature:

Multi-step reaction with 2 steps

1: nitric acid / 48 h / 20 - 50 °C

2: potassium carbonate; sodium hydroxide; dihydrogen peroxide / ethanol; water / 0 - 20 °C

With dihydrogen peroxide; nitric acid; potassium carbonate; sodium hydroxide; In ethanol; water;

Reference yield:

3,4-dihydroxybenzonitrile (17345-61-8) → 4,5-bis(2-methoxyethoxy)-2-nitrobenzamide (1172625-04-5)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 70 °C

2: nitric acid / 48 h / 20 - 50 °C

3: potassium carbonate; sodium hydroxide; dihydrogen peroxide / ethanol; water / 0 - 20 °C

With dihydrogen peroxide; nitric acid; potassium carbonate; sodium hydroxide; In ethanol; water; N,N-dimethyl-formamide;

upstream raw materials:

3,4-dihydroxybenzonitrile

3,4-bis(2-methoxyethoxy)-benzonitrile

4,5-bis(2-methoxyethoxy)-2-nitrobenzonitrile

3,4-bis(2-methoxyethoxy)benzaldehyde

Downstream raw materials:

4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

erlotinib hydrochloride

6,7-bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one

2-amino-4,5-bis[(2-methoxy)ethoxy]benzamide