4-Piperidinecarboxylic acid, 4-[[4-(4-chlorophenoxy)phenyl]sulfonyl]-1-methyl-

Base Information

• Chemical Name: 4-Piperidinecarboxylic acid, 4-[[4-(4-chlorophenoxy)phenyl]sulfonyl]-1-methyl-
• CAS No.: 239797-43-4
• Molecular Formula: C19H20ClNO5S
• Molecular Weight: 409.89
• Mol file: 239797-43-4.mol

Synonyms:

Chemical Property of 4-Piperidinecarboxylic acid, 4-[[4-(4-chlorophenoxy)phenyl]sulfonyl]-1-methyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Piperidinecarboxylic acid, 4-[[4-(4-chlorophenoxy)phenyl]sulfonyl]-1-methyl-

There total 5 articles about 4-Piperidinecarboxylic acid, 4-[[4-(4-chlorophenoxy)phenyl]sulfonyl]-1-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

4-[4-(4-chlorophenoxy)benzenesulfonyl]-1-methylpiperidine-4-carboxylic acid ethyl ester (239797-42-3) → 4-[4-(4-chlorophenoxy)benzenesulfonyl]-1-methylpiperidine-4-carboxylic acid (239797-43-4)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 72h;

DOI:10.1021/jm0205550

Reference yield:

4-sulfanylphenol (637-89-8) → 4-[4-(4-chlorophenoxy)benzenesulfonyl]-1-methylpiperidine-4-carboxylic acid (239797-43-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 100 percent / Et₃N / CHCl₃ / 2 h

2: 77 percent / NaH; CuCl₂; pyridine / 12 h / Heating

3: 99 percent / 60 percent MCPBA / CH₂Cl₂ / 6 h / 20 °C

4: 81 percent / K₂CO₃; 18-crown-6 / acetone / 16 h / Heating

5: 86 percent / 10 N aq. NaOH / methanol; tetrahydrofuran / 72 h / 20 °C

With pyridine; sodium hydroxide; 18-crown-6 ether; sodium hydride; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; copper dichloride; In tetrahydrofuran; methanol; dichloromethane; chloroform; acetone;

DOI:10.1021/jm0205550

Reference yield:

(4-Hydroxy-phenylsulfanyl)-acetic acid ethyl ester (30519-00-7) → 4-[4-(4-chlorophenoxy)benzenesulfonyl]-1-methylpiperidine-4-carboxylic acid (239797-43-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 77 percent / NaH; CuCl₂; pyridine / 12 h / Heating

2: 99 percent / 60 percent MCPBA / CH₂Cl₂ / 6 h / 20 °C

3: 81 percent / K₂CO₃; 18-crown-6 / acetone / 16 h / Heating

4: 86 percent / 10 N aq. NaOH / methanol; tetrahydrofuran / 72 h / 20 °C

With pyridine; sodium hydroxide; 18-crown-6 ether; sodium hydride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; copper dichloride; In tetrahydrofuran; methanol; dichloromethane; acetone;

DOI:10.1021/jm0205550

upstream raw materials:

4-[4-(4-chlorophenoxy)benzenesulfonyl]-1-methylpiperidine-4-carboxylic acid ethyl ester

4-sulfanylphenol

(4-Hydroxy-phenylsulfanyl)-acetic acid ethyl ester

[4-(4-chlorophenoxy)phenylsulfanyl]acetic acid ethyl ester