Gold, chloro(triethylphosphine)-

Base Information

• Chemical Name: Gold, chloro(triethylphosphine)-
• CAS No.: 15529-90-5
• Molecular Formula: C6H15 Au Cl P
• Molecular Weight: 350.578
• European Community (EC) Number: 239-572-3
• NSC Number: 313981
• Mol file: 15529-90-5.mol

Synonyms:GOLD, CHLORO(TRIETHYLPHOSPHINE)-;NSC313981;15529-90-5;C6-H15-Au-Cl-P;Chloro(triethyl-phosphine) gold;NSC-313981;NCIMech_000373;SCHEMBL1535375;CCG-35546;PD011382

Chemical Property of Gold, chloro(triethylphosphine)-

Chemical Property:

• Melting Point: 84-86 °C(lit.)
• Boiling Point: 210 °C0.03 mm Hg(lit.)
• Flash Point: 27.2°C
• PSA: 13.59000
• Density: g/cm³
• LogP: 3.21500
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 0
• Rotatable Bond Count: 3
• Exact Mass: 351.034385
• Heavy Atom Count: 9
• Complexity: 34.5

Purity/Quality:

99% ^*data from raw suppliers

Chlorotriethylphosphinegold(I), 99% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T
• Statements: 23/24/25-36/37/38
• Safety Statements: 26-28-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC[PH+](CC)CC.Cl[Au]
• Uses: Chloro(triethylphosphine)gold is an analogue of auranofin. Auranofin and its analogs show antimicrobial activity against multidrug-resistant pathogens Gold Catalysts — 21st Century ′Gold Rush′

Technology Process of Gold, chloro(triethylphosphine)-

There total 12 articles about Gold, chloro(triethylphosphine)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

gold(III) tetrachloride trihydrate + triethylphosphine (554-70-1) → (triethylphosphine)chlorogold(I) (15529-90-5)

Guidance literature:

gold(III) tetrachloride trihydrate; With 2,2'-thiobis-ethanol; In water;

triethylphosphine; In ethanol; water; at 0 - 20 ℃; for 2h;

Reference yield: 98.0%

chloro(dimethylsulfide) gold(I) (29892-37-3) + triethylphosphine (554-70-1) → (triethylphosphine)chlorogold(I) (15529-90-5)

Guidance literature:

In tetrahydrofuran; N2 atmosphere; addn. of soln of org. compd. in THF to soln. of Au-compd. in THF (0°C), stirring (15 min), warming (room temp.); concn. (vac.)pptn. on addn. of pentane, filtration, washing (pentane), drying (vac.); elem. anal.;

Reference yield: 90.0%

sodium tetrachloroaurate(III) (15189-51-2) + triethylphosphine (554-70-1) → (triethylphosphine)chlorogold(I) (15529-90-5)

Guidance literature:

In not given; byproducts: (C2H5)3PO; 2 equiv. of phosphine; elem. anal.;

DOI:10.1039/DT9790001730

upstream raw materials:

chloro(dimethylsulfide) gold(I)

triethylphosphine

sodium tetrachloroaurate(III)

(thiourea-κS)(triethylphosphine)gold(I) chloride

Downstream raw materials:

{IrAuH₃(PEt₃)(triphos)}{CF₃SO₃}

{IrAu₂H₃(PEt₃)2(triphos)}{CF₃SO₃}2

gold

[AuCl(5-(2-diphenylphosphinophenyl)-1,4,8,11-tetraazacyclotetradecane)]

Refernces

• 1、 Gienger, Christian,Schnepf, Andreas. "Neutral R3PAuGe9(Hyp)3 (R=Et, nPr, iPr, nBu, tBu, Cy) (Hyp=Si(SiMe3) Clusters give new insights into the ligand strength of the metalloid [Ge9(Hyp)3]? cluster". . p. 1695 - 1701. Retrieved 2021.
• 2、 De Paiva, Raphael E. F.,Du, Zhifeng,Farrell, Nicholas P.,Peterson, Erica J.. "The leaving group in Au(i)-phosphine compounds dictates cytotoxic pathways in CEM leukemia cells and reactivity towards a Cys2His2model zinc finger". . p. 16319 - 16328. Retrieved 2020.
• 3、 -. "GOLD COMPOSITIONS AND METHODS OF USE THEREOF". Paragraph 0075; 0117; 0118; 0120. . Retrieved 2020/03/05.