Flavodic Acid

Base Information

• Chemical Name: Flavodic Acid
• CAS No.: 37470-13-6
• Molecular Formula: C19H14O8
• Molecular Weight: 370.315
• European Community (EC) Number: 253-517-0
• UNII: 2Z9V171UEM
• DSSTox Substance ID: DTXSID90190909
• Nikkaji Number: J19.450F
• Wikidata: Q27255849
• NCI Thesaurus Code: C65690
• ChEMBL ID: CHEMBL2107394
• Mol file: 37470-13-6.mol

Synonyms:2-phenyl-5,7-dioxyacetate-benzo- gamma-pyrone;2-phenyl-gamma-benzopyrone-5,7-dioxyacetate;flavodic acid;flavodic acid sodium salt;flavodic acid, disodium salt;Intercyton;Pericel

Chemical Property of Flavodic Acid

Chemical Property:

• Boiling Point: 670.6°Cat760mmHg
• Flash Point: 245.7°C
• Density: 1.483g/cm³
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 7
• Exact Mass: 370.06886740
• Heavy Atom Count: 27
• Complexity: 607

Purity/Quality:

99% ^*data from raw suppliers

(7-CARBOXYMETHOXY-4-OXO-2-PHENYL-4H-CHROMEN-5-YLOXY)-ACETIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C=C(C=C3OCC(=O)O)OCC(=O)O

Technology Process of Flavodic Acid

There total 2 articles about Flavodic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

5,7-di-O-(ethoxycarbonyl)methyl chrysin (36086-89-2) → 5,7-di-O-carboxymethyl chrysin (37470-13-6)

Guidance literature:

With methanol; potassium hydroxide; at 40 ℃; for 2h;

DOI:10.1016/j.ejmech.2013.12.044

Reference yield:

5,7-dihydroxy-2-phenyl-chromen-4-one (480-40-0) → 5,7-di-O-carboxymethyl chrysin (37470-13-6)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 8 h / 50 °C

2: potassium hydroxide; methanol / 2 h / 40 °C

With methanol; potassium carbonate; potassium hydroxide; In acetone;

DOI:10.1016/j.ejmech.2013.12.044

upstream raw materials:

5,7-di-O-(ethoxycarbonyl)methyl chrysin

5,7-dihydroxy-2-phenyl-chromen-4-one