Synonyms:5,7-Dihydroxy-2-phenyl-4H-1-benzopyran-4-one;Flavone, 5,7-dihydroxy-;5,7-Dihydroxy-2-phenyl-4H-benzo(b)pyran-4-one;4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-phenyl- (9CI);NSC 407436;BRN 0233276;5-18-04-00076 (Beilstein Handbook Reference);5,7-Dihydroxyflavone;
99% *data from raw suppliers
Chrysin *data from reagent suppliers
Xi
There total 67 articles about Chrysin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
Reference yield: 100.0%
Reference yield: 100.0%
Reference yield: 96.0%
The research primarily investigates the binding affinity of various flavonoids to the μ-opioid receptor and evaluates the antinociceptive effects of a synthetic flavonoid, 3,3-dibromo?avanone, in mice. The study employs in vitro binding assays using [3H]DAMGO to assess the interaction of different flavonoids with μ-opioid receptors in rat forebrain membranes. The most potent compound, 3,3-dibromo?avanone, is further synthesized and tested in vivo using several pain models, including the acetic acid-induced writhing test, hot plate test, and formalin test, to evaluate its antinociceptive properties. Additional experiments assess potential side effects such as sedation, motor coordination, and gastrointestinal transit inhibition. The synthetic procedure for 3,3-dibromo?avanone is described, and its chemical structure is analyzed using techniques like NMR and EIMS. A series of natural and synthetic flavonoids were tested for their binding affinity to μ-opioid receptors. These included hesperidin, neohesperidin, naringin, rutin, hesperetin, naringenin, flavone, diosmetin, quercetin, apigenin, chrysin, among others. These compounds were obtained from Sigma-Aldrich, Extrasynthese, or were synthesized in the laboratory. The study concludes that 3,3-dibromo?avanone exhibits μ-opioid receptor activation-related antinociceptive effects without significant motor or gastrointestinal side effects, suggesting its potential as an alternative pain treatment.
The research focuses on the design and discovery of flavonoid-based HIV-1 integrase inhibitors that target both the active site of the enzyme and its interaction with LEDGF/p75. The purpose of this study is to develop novel inhibitors that can combat HIV-1 by inhibiting the viral replication process, specifically the integration of viral DNA into the host genome, which is catalyzed by HIV integrase (IN). The researchers synthesized a series of flavonoid derivatives with the aim of improving the inhibitory activity against IN and disrupting the IN-LEDGF/p75 interaction, which is crucial for viral integration. The study concluded that certain flavonoids, particularly those containing a catechol or β-ketoenol structure, showed potent inhibitory activity against both the catalytic function of IN and the IN-LEDGF/p75 interaction. Notably, the introduction of a hydrophilic morpholine group at the phenolic hydroxyl position resulted in sub- to low-micromolar IN-LEDGF/p75 inhibitory activity. The chemicals used in this process included various flavonoid derivatives, such as quercetin, baicalein, genistein, luteolin, chrysin, apigenin, and naringenin, along with synthetic reagents like acetic anhydride, benzyl bromide, potassium carbonate, and palladium catalysts for the synthesis and modification of these flavonoids.
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