6-Bromoimidazo[1,2-a]pyrazin-8-amine

Base Information

• Chemical Name: 6-Bromoimidazo[1,2-a]pyrazin-8-amine
• CAS No.: 117718-84-0
• Molecular Formula: C6H5BrN4
• Molecular Weight: 213.03
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID00151889
• Nikkaji Number: J510.332K
• Wikidata: Q72457080
• ChEMBL ID: CHEMBL111902
• Mol file: 117718-84-0.mol

Synonyms:6-bromoimidazo[1,2-a]pyrazin-8-amine;117718-84-0;8-Amino-6-bromoimidazo[1,2-a]pyrazine;BRN 5810118;Imidazo(1,2-a)pyrazin-8-amine, 6-bromo-;6-Bromoimidazo(1,2-a)pyrazin-8-amine;8-Amino-6-bromoimidazo(1,2-a)pyrazine;CHEMBL111902;Imidazo[1,2-a]pyrazin-8-amine, 6-bromo-;MFCD00874115;8-Amino-6-bromoimidazol[1,2-a]pyrazine;PAB-12;SCHEMBL5477688;DTXSID00151889;PPVWNYGAZJHXFQ-UHFFFAOYSA-N;BDBM50229882;AKOS015919484;AB07635;CS-W002705;FS-2583;AC-29910;LS-80088;SY006787;AM20070423;FT-0645405;EN300-101717;A803817;W-204955;6-(Furan-2-yl)-2-methyl-4,5-dihydropyridazin-3(2H)-one

Chemical Property of 6-Bromoimidazo[1,2-a]pyrazin-8-amine

Chemical Property:

• Refractive Index: 1.831
• PSA: 56.21000
• Density: 2.098 g/cm³
• LogP: 1.65520
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 211.96976
• Heavy Atom Count: 11
• Complexity: 154

Purity/Quality:

98%min ^*data from raw suppliers

6-Bromoimidazo[1,2-a]pyrazin-8-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN2C=C(N=C(C2=N1)N)Br

Technology Process of 6-Bromoimidazo[1,2-a]pyrazin-8-amine

There total 1 articles about 6-Bromoimidazo[1,2-a]pyrazin-8-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

6,8-dibromoimidazo[1,2-a]pyrazine (63744-22-9) → PAB 12 (117718-84-0)

Guidance literature:

With ammonia; In ethanol; at 120 ℃; for 5h;

DOI:10.1021/jm00096a008

Reference yield:

PAB 12 (117718-84-0) + phenylboronic acid (98-80-6) → 6-phenyl-imidazo[1,2-a]pyrazin-8-ylamine

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; for 24h; Heating / reflux;

Reference yield:

(4-((5-chloro-3-methyl-1H-pyrazol-4-yl)carbamoyl)-2-fluoro-5-isopropoxyphenyl)boronic acid + PAB 12 (117718-84-0) → 4-(8-aminoimidazo[1,2-a]pyrazin-6-yl)-N-(5-chloro-3-methyl-1H-pyrazol-4-yl)-5-fluoro-2-isopropoxybenzamide

Guidance literature:

With methanesulfonic acid(2-dicyclohexylphosphino-2′,4′,6′-triisopropyl-1,1′-biphenyl)[2-(2′-amino-1,1′-biphenyl)]palladium(II); potassium carbonate; In 1,4-dioxane; water; at 60 ℃; for 12h; Inert atmosphere;

upstream raw materials:

6,8-dibromoimidazo[1,2-a]pyrazine

Downstream raw materials:

imidazo[1,2-a]pyrazin-8-amine

C₂₇H₂₅N₉O

Refernces

• 1、 -. "Novel imidazopyrazines as cyclin dependent kinase inhibitors". Page/Page column 27. . Retrieved 2008/06/13.
• 2、 Bonnet, Pierre A.,Michel, Alain,Laurent, Florence,Sablayrolles, Claire,Rechencq, Eliane,et al.. "Synthesis and Antibronchospastic Activity of 8-Alkoxy- and 8-(Alkylamino)imidazopyrazines". . p. 3353 - 3358. Retrieved 2007/10/02.