Imidazo[1,2-a]pyrazin-8-amine

Base Information

• Chemical Name: Imidazo[1,2-a]pyrazin-8-amine
• CAS No.: 117718-88-4
• Molecular Formula: C6H6 N4
• Molecular Weight: 134.14
• Hs Code.: 2933990090
• European Community (EC) Number: 860-861-0
• DSSTox Substance ID: DTXSID90437402
• Nikkaji Number: J510.338J
• Wikidata: Q82252892
• ChEMBL ID: CHEMBL111812
• Mol file: 117718-88-4.mol

Synonyms:Imidazo[1,2-a]pyrazin-8-amine;117718-88-4;Imidazo[1,2-a]pyrazin-8-amine (9CI);CHEMBL111812;SCHEMBL278145;8-amino imidazo[1,2-a]pyrazine;DTXSID90437402;BDBM50241665;MFCD09835034;AKOS006281626;AB53126;Imidazo[1,2-a]pyrazin-8-amine(9ci);AS-50642;CS-0054400;EN300-72346;P10788;W-204956;Z1147460443

Chemical Property of Imidazo[1,2-a]pyrazin-8-amine

Chemical Property:

• PKA: 5.51±0.30(Predicted)
• PSA: 56.21000
• Density: 1.50±0.1 g/cm3(Predicted)
• LogP: 0.89270
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 134.059246208
• Heavy Atom Count: 10
• Complexity: 127

Purity/Quality:

97% ^*data from raw suppliers

Imidazo[1,2-a]pyrazin-8-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN2C=CN=C2C(=N1)N

Technology Process of Imidazo[1,2-a]pyrazin-8-amine

There total 2 articles about Imidazo[1,2-a]pyrazin-8-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6,8-dibromoimidazo[1,2-a]pyrazine (63744-22-9) → imidazo[1,2-a]pyrazin-8-amine (117718-88-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / ammonia / ethanol / 5 h / 120 °C

2: H₂ / Pd/C

With ammonia; hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1021/jm00096a008

Reference yield:

PAB 12 (117718-84-0) → imidazo[1,2-a]pyrazin-8-amine (117718-88-4)

Guidance literature:

With hydrogen; palladium on activated charcoal;

DOI:10.1021/jm00096a008

Reference yield: 74.0%

C21H22O6S (1374986-51-2) + imidazo[1,2-a]pyrazin-8-amine (117718-88-4) → 3-(4-(cyclopropylsulfonyl)phenoxy)-N-(imidazo[1,2-a]pyrazin-8-yl)-5-((3-methylbut-2-en-1-yl)oxy)benzamide (1374986-65-8)

Guidance literature:

With 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 60 ℃; for 0.5h; Microwave irradiation;

DOI:10.1016/j.bmc.2012.03.008

upstream raw materials:

PAB 12

6,8-dibromoimidazo[1,2-a]pyrazine

Downstream raw materials:

3-(4-(cyclopropylsulfonyl)phenoxy)-N-(imidazo[1,2-a]pyrazin-8-yl)-5-((3-methylbut-2-en-1-yl)oxy)benzamide