[1,2,4]Triazolo[1,5-a]pyrimidin-7-amine, 5-chloro-N-[(1S)-2,2,2-trifluoro-1-methylethyl]-6-(2,4,6-trifluorophenyl)-

Base Information

Chemical Name:[1,2,4]Triazolo[1,5-a]pyrimidin-7-amine, 5-chloro-N-[(1S)-2,2,2-trifluoro-1-methylethyl]-6-(2,4,6-trifluorophenyl)-
CAS No.:249648-16-6
Molecular Formula:C14H8ClF6N5
Molecular Weight:395.694
Hs Code.:
Mol file:249648-16-6.mol

Synonyms:5-chloro-6-(2,4,6-trifluorophenyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl-(S)-(2,2,2-trifluoro-1-methylethyl)amine;5-chloro-N-[(1S)-2,2,2-trifluoro-1-methylethyl]-6-(2,4,6-trifluoro-phenyl)[1,2,4]triazolo[1,5-a]pyrimidine-7-amine;[5-chloro-6-(2,4,6-trifluoro-phenyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl]-((1S)-2,2,2-trifluoro-1-methyl-ethyl)-amine;5-chloro-6-(2,4,6-trifluorophenyl)-N-[(1S)-2,2,2-trifluoro-1-methylethyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine;5-chloro-6-(2,4,6-trifluorophenyl)-7-(1,1,1-trifluoroprop-2-ylamino)-[1,2,4]triazolo[1,5-a]pyrimidine;(S)-5-chloro-6-(2,4,6-trifluorophenyl)-N-(1,1,1-trifluoropropan-2-yl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine;

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [1,2,4]Triazolo[1,5-a]pyrimidin-7-amine, 5-chloro-N-[(1S)-2,2,2-trifluoro-1-methylethyl]-6-(2,4,6-trifluorophenyl)-

Chemical Property:

Melting Point:124-126 °C
PSA：55.11000
Density:1.69±0.1 g/cm3(Predicted)
LogP:4.29770

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of [1,2,4]Triazolo[1,5-a]pyrimidin-7-amine, 5-chloro-N-[(1S)-2,2,2-trifluoro-1-methylethyl]-6-(2,4,6-trifluorophenyl)-

There total 7 articles about [1,2,4]Triazolo[1,5-a]pyrimidin-7-amine, 5-chloro-N-[(1S)-2,2,2-trifluoro-1-methylethyl]-6-(2,4,6-trifluorophenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 125353-44-8,2968-32-3
(S)-2,2,2-trifluoro-1-(methyl)ethylamine hydrochloride

: 214707-02-5
5,7-dichloro-6-(2,4,6-trifluorophenyl)-[1,2,4]triazolo[1,5-a]pyrimidine

: 249648-16-6
5-chloro-N-[(1S)-2,2,2-trifluoro-1-methylethyl]-6-(2,4,6-trifluorophenyl)-[1,2,4]triazolo[1,5-a]pyrimidine-7-amine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 13h;
DOI:10.1021/jm060717i

Reference yield: 82.0%

: 125278-10-6,779303-24-1
(S)-1,1,1-trifluoropropan-2-amine

: 214707-02-5
5,7-dichloro-6-(2,4,6-trifluorophenyl)-[1,2,4]triazolo[1,5-a]pyrimidine

: 249648-16-6
5-chloro-N-[(1S)-2,2,2-trifluoro-1-methylethyl]-6-(2,4,6-trifluorophenyl)-[1,2,4]triazolo[1,5-a]pyrimidine-7-amine

Guidance literature:: (S)-1,1,1-trifluoropropan-2-amine; 5,7-dichloro-6-(2,4,6-trifluorophenyl)-[1,2,4]triazolo[1,5-a]pyrimidine; In N,N-dimethyl-formamide; at 20 - 30 ℃; for 24h;

With water; at 10 - 20 ℃; for 0.5h;