2-Bromo-4-(2,2-dimethyl-1,3-dioxolane-4-ylmethyl)phenol

Base Information

Chemical Name:2-Bromo-4-(2,2-dimethyl-1,3-dioxolane-4-ylmethyl)phenol
CAS No.:250284-68-5
Molecular Formula:C12H15BrO3
Molecular Weight:287.153
Hs Code.:
DSSTox Substance ID:DTXSID701202321
Nikkaji Number:J2.142.239H

Synonyms:2-bromo-4-[(2,2-dimethyl-1,3-dioxolan-4-yl)methyl]phenol;DTXSID701202321;2-Bromo-4-(2,2-dimethyl-1,3-dioxolane-4-ylmethyl)phenol;250284-68-5

Suppliers and Price of 2-Bromo-4-(2,2-dimethyl-1,3-dioxolane-4-ylmethyl)phenol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Bromo-4-(2,2-dimethyl-1,3-dioxolane-4-ylmethyl)phenol

Chemical Property:

XLogP3:2.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:286.02046
Heavy Atom Count:16
Complexity:244

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1(OCC(O1)CC2=CC(=C(C=C2)O)Br)C

Technology Process of 2-Bromo-4-(2,2-dimethyl-1,3-dioxolane-4-ylmethyl)phenol

There total 5 articles about 2-Bromo-4-(2,2-dimethyl-1,3-dioxolane-4-ylmethyl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1026519-65-2
4-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-phenol

: 250284-68-5
2-bromo-4-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-phenol

Guidance literature:: With N-Bromosuccinimide; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/S0040-4039(99)01429-X

Reference yield:

: 6793-92-6
p-benzyloxyphenylbromide

: 250284-68-5
2-bromo-4-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-phenol

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / Mg / tetrahydrofuran / Heating

2: 99 percent / K₂OsO₂(OH)2; K₂CO₃; K₃Fe(CN)6 / 2-methyl-propan-2-ol; H₂O / 20 °C

3: 95 percent / 2,2-dimethoxypropane; PPTS / 20 °C

4: 99 percent / hydrogen / 10 percent Pd/C / ethyl acetate / 20 °C

5: 87 percent / NBS / dimethylformamide / 20 °C

With N-Bromosuccinimide; K₂OsO₂(OH)2; hydrogen; pyridinium p-toluenesulfonate; potassium carbonate; magnesium; 2,2-dimethoxy-propane; potassium hexacyanoferrate(III); palladium on activated charcoal; In tetrahydrofuran; water; ethyl acetate; N,N-dimethyl-formamide; tert-butyl alcohol; 1: Alkylation / 2: Oxidation / 3: acetonization / 4: Reduction / 5: Bromination;
DOI:10.1016/S0040-4039(99)01429-X

Reference yield:

: 90617-59-7
1-(benzyloxy)-4-(prop-2-en-1-yl)benzene

: 250284-68-5
2-bromo-4-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-phenol

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / K₂OsO₂(OH)2; K₂CO₃; K₃Fe(CN)6 / 2-methyl-propan-2-ol; H₂O / 20 °C

2: 95 percent / 2,2-dimethoxypropane; PPTS / 20 °C

3: 99 percent / hydrogen / 10 percent Pd/C / ethyl acetate / 20 °C

4: 87 percent / NBS / dimethylformamide / 20 °C

With N-Bromosuccinimide; K₂OsO₂(OH)2; hydrogen; pyridinium p-toluenesulfonate; potassium carbonate; 2,2-dimethoxy-propane; potassium hexacyanoferrate(III); palladium on activated charcoal; In water; ethyl acetate; N,N-dimethyl-formamide; tert-butyl alcohol; 1: Oxidation / 2: acetonization / 3: Reduction / 4: Bromination;
DOI:10.1016/S0040-4039(99)01429-X