Thymidine, 5'-(2-oxo-2-phenylethyl carbonate)

Base Information

• Chemical Name: Thymidine, 5'-(2-oxo-2-phenylethyl carbonate)
• CAS No.: 252979-74-1
• Molecular Formula: C19H20N2O8
• Molecular Weight: 404.376
• Mol file: 252979-74-1.mol

Synonyms:

Chemical Property of Thymidine, 5'-(2-oxo-2-phenylethyl carbonate)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Thymidine, 5'-(2-oxo-2-phenylethyl carbonate)

There total 5 articles about Thymidine, 5'-(2-oxo-2-phenylethyl carbonate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

1-phenyl-2-hydroxyethanone (582-24-1) + 1,1'-carbonyldiimidazole (530-62-1) + methyl trifluoromethanesulfonate (333-27-7) + thymidine (50-89-5,28854-96-8,3545-96-8,50-88-4) → phenacyl 5'-thymidine carbonate (252979-74-1)

Guidance literature:

Reference yield: 48.0%

1-phenyl-2-hydroxyethanone (582-24-1) + thymidine (50-89-5,28854-96-8,3545-96-8,50-88-4) → phenacyl 5'-thymidine carbonate (252979-74-1)

Guidance literature:

Reference yield:

α-bromoacetophenone (70-11-1) → phenacyl 5'-thymidine carbonate (252979-74-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 86 percent / sodium formate / ethanol / 20 h / 105 °C

2.1: nitromethane / 1 h / 0 - 20 °C

2.2: nitromethane / 2 h / 20 °C

3.1: 3.7 g / nitromethane

With sodium formate; In nitromethane; ethanol; 1.1: Substitution / 2.1: Methylation / 2.2: Substitution / 3.1: Esterification;

DOI:10.1016/S0040-4020(99)00754-1

upstream raw materials:

thymidine

1-phenyl-2-hydroxyethanone

α-bromoacetophenone

1,1'-carbonyldiimidazole

Downstream raw materials:

thymidine

1,2-bis(10-methyl-9-anthryl)ethane

phenacylacetophenone