Cyclopentanecarboxylic acid, 3-amino-, hydrochloride, cis- (8CI,9CI)

Base Information

• Chemical Name: Cyclopentanecarboxylic acid, 3-amino-, hydrochloride, cis- (8CI,9CI)
• CAS No.: 19042-35-4
• Molecular Formula: C6H11NO2
• Molecular Weight: 129.157
• Mol file: 19042-35-4.mol

Synonyms:

Chemical Property of Cyclopentanecarboxylic acid, 3-amino-, hydrochloride, cis- (8CI,9CI)

Chemical Property:

• Vapor Pressure: 0.00278mmHg at 25°C
• Boiling Point: 264.7°Cat760mmHg
• Flash Point: 113.9°C
• PSA: 63.32000
• Density: 1.19g/cm³
• LogP: 1.70070
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

cis-3-Aminocyclopentane-1-carboxylicacidhydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclopentanecarboxylic acid, 3-amino-, hydrochloride, cis- (8CI,9CI)

There total 19 articles about Cyclopentanecarboxylic acid, 3-amino-, hydrochloride, cis- (8CI,9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(1R,3R)-3-((tert-butoxycarbonyl)amino)cyclopentane-1-carboxylic acid (489446-85-7) → (1R,3R)-3-aminocyclopentane-1-carboxylic acid hydrochloride (1203306-05-1,1392803-15-4,19042-35-4,147780-44-7)

Guidance literature:

(1R,3R)-3-((tert-butoxycarbonyl)amino)cyclopentane-1-carboxylic acid; In dichloromethane; at 20 ℃; for 2h;

With hydrogenchloride; In 1,4-dioxane;

Reference yield: 93.0%

2-Azabicyclo[2.2.1]heptan-3-one (24647-29-8) → cis-3-aminocyclopentanecarboxylic acid hydrochloride (1203306-05-1,1392803-15-4,19042-35-4,147780-44-7)

Guidance literature:

With hydrogenchloride; at 20 ℃; for 48h;

DOI:10.1002/anie.200501555

Reference yield: 87.2%

1-azabicyclo[2.2.1]heptan-3-one (21472-89-9) → (1S,3R)-3-aminocyclopentanecarboxylic acid hydrochloride salt (1203306-05-1,1392803-15-4,19042-35-4,147780-44-7)

Guidance literature:

With hydrogenchloride; for 4h; Reflux;

upstream raw materials:

(1S,4R)-N-(9-Phenylfluoren-9-yl)-2-azabicyclo<2.2.1>heptan-3-one

(-)-2-Azabicyclo<2.2.1>heptan-3-one

1-azabicyclo[2.2.1]heptan-3-one

(1S,3R)-3-(tert-butoxycarbonylamino)cyclopentanecarboxylic acid

Downstream raw materials:

(1R,3S)-3-((tert-butoxycarbonyl)amino)cyclopentane-1-carboxylic acid

(1S,3R)-3-(tert-butoxycarbonylamino)cyclopentanecarboxylic acid

(1R,3S)-methyl 3-aminocyclopentanecarboxylate hydrochloride

Refernces

• 1、 -. "PYRAZOLO-PYRIMIDIN-AMINO-CYCLOALKYL COMPOUNDS AND THEIR THERAPEUTIC USES". . . Retrieved 2019/12/28.
• 2、 Galla, Zsolt,Forró, Enik?,Fül?p, Ferenc. "Enhanced enzymatic synthesis of the enantiopure intermediate for the blockbuster drug intermediate abacavir through a two-step enzymatic cascade reaction". . p. 729 - 731. Retrieved 2016/08/01.