2,6-Bis-benzyloxybenzaldehyde

Base Information

• Chemical Name: 2,6-Bis-benzyloxybenzaldehyde
• CAS No.: 25983-53-3
• Molecular Formula: C21H18O3
• Molecular Weight: 318.372
• DSSTox Substance ID: DTXSID40471194
• Nikkaji Number: J895.229I
• Wikidata: Q82299645
• Mol file: 25983-53-3.mol

Synonyms:2,6-Bis-benzyloxybenzaldehyde;25983-53-3;SCHEMBL3923636;DTXSID40471194;HODTWSSKUTVXMG-UHFFFAOYSA-N

Chemical Property of 2,6-Bis-benzyloxybenzaldehyde

Chemical Property:

• XLogP3: 4.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 7
• Exact Mass: 318.125594432
• Heavy Atom Count: 24
• Complexity: 328

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC2=C(C(=CC=C2)OCC3=CC=CC=C3)C=O

Technology Process of 2,6-Bis-benzyloxybenzaldehyde

There total 20 articles about 2,6-Bis-benzyloxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2,6-dibenzyloxybenzyl alcohol (25983-52-2) → 3-((3-(benzyloxy)-2-formylphenoxy)methyl)benzene (25983-53-3)

Guidance literature:

With pyridinium chlorochromate; In dichloromethane; for 5.5h; Ambient temperature;

DOI:10.1246/bcsj.64.3005

Reference yield: 97.0%

2,6-dihydroxybenzaldehyde (387-46-2) + benzyl bromide (100-39-0) → 3-((3-(benzyloxy)-2-formylphenoxy)methyl)benzene (25983-53-3)

Guidance literature:

With potassium carbonate; In acetonitrile; for 2h; Reflux;

DOI:10.1039/c5cc01572c

Reference yield: 71.6%

N-Formylpiperidine (2591-86-8) + 1,3-bis(benzyloxy)benzene (3769-42-4) → 3-((3-(benzyloxy)-2-formylphenoxy)methyl)benzene (25983-53-3)

Guidance literature:

1,3-bis(benzyloxy)benzene; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In diethyl ether; hexane; at 20 ℃; for 3h; Inert atmosphere;

N-Formylpiperidine; In hexane; dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1002/asia.200900679

upstream raw materials:

2,6-dibenzyloxybenzyl alcohol

2,6-dihydroxybenzaldehyde

benzyl bromide

1,3-bis(benzyloxy)benzene

Downstream raw materials:

3,5-dibenzyloxy-4-(2,6-dibenzyloxybenzylhydroxy)benzoic acid 1,1-dimethylethyl ester