L-Proline, O-(1,1-dimethyl-2-propenyl)-N-[[(4-nitrophenyl)methoxy]carbonyl]-L-seryl -L-phenylalanylthio-L-prolyl-L-seryl-L-isoleucyl-, methyl ester

Base Information

Chemical Name:L-Proline, O-(1,1-dimethyl-2-propenyl)-N-[[(4-nitrophenyl)methoxy]carbonyl]-L-seryl -L-phenylalanylthio-L-prolyl-L-seryl-L-isoleucyl-, methyl ester
CAS No.:260782-45-4
Molecular Formula:C45H61N7O12S
Molecular Weight:924.085
Hs Code.:

L-Proline,
O-(1,1-dimethyl-2-propenyl)-N-[[(4-nitrophenyl)methoxy]carbonyl]-L-seryl
-L-phenylalanylthio-L-prolyl-L-seryl-L-isoleucyl-, methyl ester

Synonyms:

Suppliers and Price of L-Proline, O-(1,1-dimethyl-2-propenyl)-N-[[(4-nitrophenyl)methoxy]carbonyl]-L-seryl -L-phenylalanylthio-L-prolyl-L-seryl-L-isoleucyl-, methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of L-Proline, O-(1,1-dimethyl-2-propenyl)-N-[[(4-nitrophenyl)methoxy]carbonyl]-L-seryl -L-phenylalanylthio-L-prolyl-L-seryl-L-isoleucyl-, methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of L-Proline, O-(1,1-dimethyl-2-propenyl)-N-[[(4-nitrophenyl)methoxy]carbonyl]-L-seryl -L-phenylalanylthio-L-prolyl-L-seryl-L-isoleucyl-, methyl ester

There total 13 articles about L-Proline, O-(1,1-dimethyl-2-propenyl)-N-[[(4-nitrophenyl)methoxy]carbonyl]-L-seryl -L-phenylalanylthio-L-prolyl-L-seryl-L-isoleucyl-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 260782-44-3
(S)-3-(1,1-Dimethyl-allyloxy)-2-(4-nitro-benzyloxycarbonylamino)-propionic acid

: 773052-16-7
(S)-1-[(2S,3S)-2-((S)-2-{[(S)-1-((S)-2-Amino-3-phenyl-propionyl)-pyrrolidine-2-carbothioyl]-amino}-3-hydroxy-propionylamino)-3-methyl-pentanoyl]-pyrrolidine-2-carboxylic acid methyl ester

: 260782-45-4
1-(2-{2-[(1-{2-[3-(1,1-dimethyl-allyloxy)-2-(4-nitro-benzyloxycarbonylamino)-propionylamino]-3-phenyl-propionyl}-pyrrolidine-2-carbothioyl)-amino]-3-hydroxy-propionylamino}-3-methyl-pentanoyl)-pyrrolidine-2-carboxylic acid methyl ester

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1016/S0040-4039(99)01955-3

Reference yield:

: 111193-37-4
1-(p-nitrobenzyloxycarbonyl)aziridine-2S-carboxylic acid methyl ester

: 260782-45-4
1-(2-{2-[(1-{2-[3-(1,1-dimethyl-allyloxy)-2-(4-nitro-benzyloxycarbonylamino)-propionylamino]-3-phenyl-propionyl}-pyrrolidine-2-carbothioyl)-amino]-3-hydroxy-propionylamino}-3-methyl-pentanoyl)-pyrrolidine-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / BF₃*Et₂O / CH₂Cl₂ / 120 h / 20 °C

2: LiOH / methanol; tetrahydrofuran / 1.5 h / 20 °C

3: 79 mg / diisopropylethylamine; HOBt; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 24 h / 0 - 20 °C

With lithium hydroxide; boron trifluoride diethyl etherate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0040-4020(03)00293-X

Reference yield:

: 260782-48-7
(S)-3-(1,1-Dimethyl-allyloxy)-2-(4-nitro-benzyloxycarbonylamino)-propionic acid methyl ester

: 260782-45-4
1-(2-{2-[(1-{2-[3-(1,1-dimethyl-allyloxy)-2-(4-nitro-benzyloxycarbonylamino)-propionylamino]-3-phenyl-propionyl}-pyrrolidine-2-carbothioyl)-amino]-3-hydroxy-propionylamino}-3-methyl-pentanoyl)-pyrrolidine-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: LiOH / methanol; tetrahydrofuran / 1.5 h / 20 °C

2: 79 mg / diisopropylethylamine; HOBt; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 24 h / 0 - 20 °C

With lithium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0040-4020(03)00293-X