2,6-Dichloro-1,5-naphthyridine

Base Information

• Chemical Name: 2,6-Dichloro-1,5-naphthyridine
• CAS No.: 27017-66-9
• Molecular Formula: C8H4Cl2N2
• Molecular Weight: 199.039
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID70345879
• Nikkaji Number: J99.584C
• Wikidata: Q82118664
• Mol file: 27017-66-9.mol

Synonyms:2,6-Dichloro-1,5-naphthyridine;27017-66-9;1,5-Naphthyridine, 2,6-dichloro-;2,6-dichloro-[1,5]naphthyridine;SCHEMBL1294228;DTXSID70345879;ZB0088;AKOS016005217;AB16862;2,6-bis(chloranyl)-1,5-naphthyridine;E84476;A818839

Chemical Property of 2,6-Dichloro-1,5-naphthyridine

Chemical Property:

• Melting Point: 236-238 °C
• Boiling Point: 299.8±35.0 °C(Predicted)
• PKA: -0.45±0.10(Predicted)
• PSA: 25.78000
• Density: 1.486±0.06 g/cm3(Predicted)
• LogP: 2.93660
• Storage Temp.: 2-8°C
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 197.9751535
• Heavy Atom Count: 12
• Complexity: 147

Purity/Quality:

99.3% ^*data from raw suppliers

2,6-Dichloro-1,5-naphthyridine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=NC2=C1N=C(C=C2)Cl)Cl
• Uses: 2,?6-?Dichloro-?1,?5-?naphthyridine is a reagent used in the preparation of potential tau pathology PET tracers in the treatment of Alzheimer’s disease.

Technology Process of 2,6-Dichloro-1,5-naphthyridine

There total 9 articles about 2,6-Dichloro-1,5-naphthyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

→ 2,6-dichloro-1,5-naphthyridine (27017-66-9)

Guidance literature:

Reference yield: 35.0%

1,5-naphthyridine (254-79-5) → 2,6-dichloro-1,5-naphthyridine (27017-66-9)

Guidance literature:

DOI:10.1021/jo00318a001

Reference yield: 15.0%

1,5-naphthyridine 1,5-dioxide (27305-49-3) → 2,6-dichloro-1,5-naphthyridine (27017-66-9)

Guidance literature:

With trichlorophosphate; at 0 ℃; for 0.5h; Reflux;

upstream raw materials:

1,5-naphthyridine 1,5-dioxide

1,5-naphthyridine

trichlorophosphate

pyridin-3-ylamine

Downstream raw materials:

1,5-dihydro-1,5-naphthyridine-2,6-dione

Refernces

• 1、 Lee, Youngnam,Woo, Seung-Je,Kim, Jang-Joo,Hong, Jong-In. "Linear-shaped thermally activated delayed fluorescence emitter using 1,5-naphthyridine as an electron acceptor for efficient light extraction". . . Retrieved 2019/12/27.
• 2、 -. "SUBSTITUTED NAPHTHYRIDINES AS ACCEPTOR MOLECULES FOR ELECTRONIC DEVICES". Page/Page column 45. . Retrieved 2015/02/25.