Benzenemethanol, a-[(4-bromophenyl)ethynyl]-

Base Information

• Chemical Name: Benzenemethanol, a-[(4-bromophenyl)ethynyl]-
• CAS No.: 278168-69-7
• Molecular Formula: C15H11BrO
• Molecular Weight: 287.156

Synonyms:

Chemical Property of Benzenemethanol, a-[(4-bromophenyl)ethynyl]-

Chemical Property:

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SDS file from LookChem

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Technology Process of Benzenemethanol, a-[(4-bromophenyl)ethynyl]-

There total 2 articles about Benzenemethanol, a-[(4-bromophenyl)ethynyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

4-bromo-1-ethynylbenzene (766-96-1) + benzaldehyde (100-52-7) → 3-(4-bromophenyl)-1-phenylprop-2-yn-1-ol (278168-69-7)

Guidance literature:

4-bromo-1-ethynylbenzene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Inert atmosphere;

benzaldehyde; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1021/acs.joc.1c02685

Reference yield:

1-phenyl-3-trimethylsilylprop-2-yn-1-ol (89530-34-7) + 4-bromobenzenediazonium tetrafluoroborate (673-40-5) → 3-(4-bromophenyl)-1-phenylprop-2-yn-1-ol (278168-69-7)

Guidance literature:

1-phenyl-3-trimethylsilylprop-2-yn-1-ol; 4-bromobenzenediazonium tetrafluoroborate; With tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; [bis(trifluoromethanesulfonyl)imidate](triphenylphosphine)gold(I); In methanol; acetonitrile; at -78 ℃; for 0.0833333h; Schlenk technique; Darkness; Inert atmosphere;

In methanol; acetonitrile; at -78 - -20 ℃; for 0.166667h; Schlenk technique; Inert atmosphere; UV-irradiation;

DOI:10.1021/acs.joc.6b03006

Reference yield: 88.0%

benzoxazole (273-53-0,29791-96-6) + 3-(4-bromophenyl)-1-phenylprop-2-yn-1-ol (278168-69-7) → C22H16BrNO2

Guidance literature:

With ytterbium(III) triflate; In acetonitrile; at 80 ℃; for 2.5h;

DOI:10.1002/cctc.201600606

upstream raw materials:

4-bromo-1-ethynylbenzene

benzaldehyde

1-phenyl-3-trimethylsilylprop-2-yn-1-ol

4-bromobenzenediazonium tetrafluoroborate

Downstream raw materials:

1-bromo-4-(3-phenylprop-1-yn-1-yl)benzene

C₂₁H₁₇BrOS₂

5-bromo-3-phenyl-2-(phenylthio)-1H-inden-1-one

2,3-dihydro-2-phenyl-4-(4-bromophenyl)-1H-1,5-benzodiazepine

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