1-Methoxypropan-2-yl methanesulfonate

Base Information

• Chemical Name: 1-Methoxypropan-2-yl methanesulfonate
• CAS No.: 24590-51-0
• Molecular Formula: C5H12 O4 S
• Molecular Weight: 168.214
• European Community (EC) Number: 873-330-3
• NSC Number: 59364
• Nikkaji Number: J811.315G
• Mol file: 24590-51-0.mol

Synonyms:1-methoxypropan-2-yl methanesulfonate;24590-51-0;1-Methoxy-2-propanol methanesulfonate;NSC59364;NSC 59364;2-Propanol, 1-methoxy-, methanesulfonate;2-Propanol, methanesulfonate;SCHEMBL711729;OFLUAKABUQZNOY-UHFFFAOYSA-N;1-methoxy-2-propyl methanesulfonate;1-methoxypropan-2-ylmethanesulfonate;NSC-59364;2-Methoxy-1-methylethyl Methanesulphonate;EN300-133457

Chemical Property of 1-Methoxypropan-2-yl methanesulfonate

Chemical Property:

• Vapor Pressure: 0.0159mmHg at 25°C
• Refractive Index: 1.429
• Boiling Point: 264.4°Cat760mmHg
• Flash Point: 113.7°C
• Density: 1.158g/cm³
• XLogP3: -0.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 168.04563003
• Heavy Atom Count: 10
• Complexity: 167

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(COC)OS(=O)(=O)C

Technology Process of 1-Methoxypropan-2-yl methanesulfonate

There total 2 articles about 1-Methoxypropan-2-yl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-methoxy-2-propanol (107-98-2) + methanesulfonyl chloride (124-63-0) → (+/-)-(methoxyprop-2-yl) methanesulphonate (24590-51-0)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 1h;

DOI:10.1021/acs.jmedchem.6b00554

Reference yield:

→ (+/-)-(methoxyprop-2-yl) methanesulphonate (24590-51-0)

Guidance literature:

With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.5h;

In tetrahydrofuran; mineral oil; at 20 ℃; for 4h;

Reference yield: 75.0%

(+/-)-(methoxyprop-2-yl) methanesulphonate (24590-51-0) + aniline (62-53-3) → N-(2-Methoxy-1-methylethyl)aniline (78923-90-7)

Guidance literature:

With triethylamine; In benzene; for 40h; Heating;

DOI:10.1016/S0040-4020(01)00285-X

upstream raw materials:

1-methoxy-2-propanol

methanesulfonyl chloride

Downstream raw materials:

2-Methoxyisopropyl(phenyl)selenid

N-(2-Methoxy-1-methylethyl)aniline

6-(6-amino-5-chloro-2-phenyl-3-pyridyl)-2-(2-methoxy-1-methylethyl)-3(2H)-pyridazinone

C₁₃H₂₀N₂O₅S

Refernces

• 1、 Lu, Hongfu,Yang, Ting,Xu, Zhongmiao,Lin, Xichen,Ding, Qian,Zhang, Yueting,Cai, Xin,Dong, Kelly,Gong, Sophie,Zhang, Wei,Patel, Metul,Copley, Royston C. B.,Xiang, Jianing,Guan, Xiaoming,Wren, Paul,Ren, Feng. "Discovery of Novel 1-Cyclopentenyl-3-phenylureas as Selective, Brain Penetrant, and Orally Bioavailable CXCR2 Antagonists". supporting information. p. 2518 - 2532. Retrieved 2018/03/26.
• 2、 -. "1 -(CYCLOPENT-2-EN-1 -YL)-3-(2-HYDROXY-3-(ARYLSULFONYL)PHENYL)UREA DERIVATIVES AS CXCR2 INHIBITORS". Page/Page column 166. . Retrieved 2015/12/18.