2-AMino-N-(5-chloropyridin-2-yl)-5-MethoxybenzaMide

Base Information

• Chemical Name: 2-AMino-N-(5-chloropyridin-2-yl)-5-MethoxybenzaMide
• CAS No.: 280773-17-3
• Molecular Formula: C13H12ClN3O2
• Molecular Weight: 277.71
• Hs Code.: 2933399090
• Mol file: 280773-17-3.mol

Synonyms:2-Amino-N-(5-chloro-2-pyridinyl)-5-methoxybenzam;

Chemical Property of 2-AMino-N-(5-chloropyridin-2-yl)-5-MethoxybenzaMide

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.671
• Boiling Point: 396.864 °C at 760 mmHg
• PKA: 11.19±0.70(Predicted)
• Flash Point: 193.816 °C
• PSA: 80.73000
• Density: 1.39 g/cm³
• LogP: 3.54330
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98% ^*data from raw suppliers

2-Amino-N-(5-chloropyridin-2-yl)-5-methoxybenzamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMino-N-(5-chloropyridin-2-yl)-5-MethoxybenzaMide

There total 5 articles about 2-AMino-N-(5-chloropyridin-2-yl)-5-MethoxybenzaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

5-methoxy-2-nitro-N-(5-chloro-pyridine-2-yl)benzamide (280773-16-2) → 2-amino-N-(5-chloro-pyridin-2-yl)-5-methoxy-benzamide (280773-17-3)

Guidance literature:

With iron(III) chloride; hydrazine hydrate; In methanol; for 6h; Reflux;

Reference yield: 85.72%

5-chloro-2-pyridylamine (1072-98-6) + 6-methoxy-2H-3,1-benzoxazine-2,4(1H)-dione (37795-77-0) → 2-amino-N-(5-chloro-pyridin-2-yl)-5-methoxy-benzamide (280773-17-3)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at 20 - 25 ℃; for 1h; Solvent; Temperature; Reagent/catalyst; Inert atmosphere;

Reference yield:

5-methoxy-2-nitro-benzoic acid (1882-69-5) → 2-amino-N-(5-chloro-pyridin-2-yl)-5-methoxy-benzamide (280773-17-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: pyridine / acetonitrile / 19 - 25 °C / Industry scale

1.2: 19 - 28 °C / Industry scale

1.3: 12 - 30 °C / Industry scale

2.1: hydrogen / platinum on carbon / dichloromethane / 16.5 h / 25 - 31 °C / 1551.49 Torr / Industry scale

With pyridine; hydrogen; platinum on carbon; In dichloromethane; acetonitrile;

upstream raw materials:

5-methoxy-2-nitro-N-(5-chloro-pyridine-2-yl)benzamide

5-methoxy-2-nitro-benzoic acid

5-chloro-2-pyridylamine

6-methoxy-2H-3,1-benzoxazine-2,4(1H)-dione

Downstream raw materials:

2-[(1-tert-butoxycarbonylpiperidin-4-ylcarbonyl)amino]-N-(5-chloropyridin-2-yl)-5-methoxybenzamide

N-(5-chloro(2-pyridyl)){2-[(4-cyanophenyl)carbonylamino]-5-methoxyphenyl}carboxamide

betrixaban

N-(5-chloropyridine-2-yl)-2-[4-(trifluoroacetyl(methyl)amino)-2-(3-(trifluoroacetylamino)propoxy)phenylcarbonylamino]-5-methoxybenzamide