4-Ethoxy-3-methoxyphenethyl alcohol

Base Information

• Chemical Name: 4-Ethoxy-3-methoxyphenethyl alcohol
• CAS No.: 77891-29-3
• Molecular Formula: C11H16 O3
• Molecular Weight: 196.246
• Hs Code.: 2909499000
• European Community (EC) Number: 278-787-7
• DSSTox Substance ID: DTXSID60999082
• Nikkaji Number: J307.952J
• Wikidata: Q82991931
• Mol file: 77891-29-3.mol

Synonyms:4-Ethoxy-3-methoxyphenethyl alcohol;77891-29-3;EINECS 278-787-7;2-(4-ethoxy-3-methoxyphenyl)ethan-1-ol;Benzeneethanol, 4-ethoxy-3-methoxy-;2-(4-Ethoxy-3-methoxyphenyl)ethanol;SCHEMBL5873476;4-Ethoxy-3-methoxybenzeneethanol;DTXSID60999082;AKOS006282602;2-(4-Ethoxy-3-methoxyphenyl)ethanol #;4-Ethoxy-3-methoxyphenethyl alcohol, 99%;EN300-1853539;1-(4'-ethoxy-3'-methoxyphenyl)-2-hydroxy-ethane

Chemical Property of 4-Ethoxy-3-methoxyphenethyl alcohol

Chemical Property:

• Vapor Pressure: 0.00061mmHg at 25°C
• Boiling Point: 297.3°C at 760 mmHg
• PKA: 14.80±0.10(Predicted)
• Flash Point: 137.1°C
• PSA: 38.69000
• Density: 1.064g/cm³
• LogP: 1.62870
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 196.109944368
• Heavy Atom Count: 14
• Complexity: 150

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=C(C=C(C=C1)CCO)OC

Technology Process of 4-Ethoxy-3-methoxyphenethyl alcohol

There total 6 articles about 4-Ethoxy-3-methoxyphenethyl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

vanillin (121-33-5,8014-42-4) → 2-(4-ethoxy-3-methoxyphenyl)ethanol (77891-29-3)

Guidance literature:

Multi-step reaction with 3 steps

1: piperidine / toluene / Reflux

2: cetyltrimethylammonim bromide; sodium hydroxide / dichloromethane / 80 °C

3: sodium tetrahydroborate; boron trifluoride diethyl etherate; dihydrogen peroxide; sodium hydroxide / 20 °C

With piperidine; sodium tetrahydroborate; boron trifluoride diethyl etherate; dihydrogen peroxide; cetyltrimethylammonim bromide; sodium hydroxide; In dichloromethane; toluene; 1: Knoevenagel condensation;

DOI:10.1111/j.1747-0285.2011.01093.x

Reference yield:

methyl 4-ethoxy-3-methoxyphenylacetate (55761-07-4) → 2-(4-ethoxy-3-methoxyphenyl)ethanol (77891-29-3)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; benzene;

Reference yield:

4-(4-ethoxy-3-methoxy-benzylidene)-2-phenyl-4H-oxazol-5-one (5681-17-4) → 2-(4-ethoxy-3-methoxyphenyl)ethanol (77891-29-3)

Guidance literature:

Multi-step reaction with 2 steps

2: LiAlH₄ / diethyl ether; benzene

With lithium aluminium tetrahydride; In diethyl ether; benzene;

upstream raw materials:

methyl 4-ethoxy-3-methoxyphenylacetate

4-(4-ethoxy-3-methoxy-benzylidene)-2-phenyl-4H-oxazol-5-one

3-methoxy-4-hydroxystyrene

4-Ethoxy-3-methoxystyrol

Downstream raw materials:

3-[2-(4-ethoxy-3-methoxy-phenyl)-ethoxy]-2-hydroxy-3,3-diphenyl-propionic acid methyl ester

3-[2-(4-ethoxy-3-methoxy-phenyl)-ethoxy]-2-hydroxy-3,3-diphenyl-propionic acid

6-Methoxy-7-ethoxy-1-(3-methoxy-4-ethoxy-phenyl)-naphthalin

1-Hydroxy-1,4-bis-(3-methoxy-4-ethoxy-phenyl)-butan