5,6-Dichloro-1,2-dimethylbenzimidazole

Base Information

• Chemical Name: 5,6-Dichloro-1,2-dimethylbenzimidazole
• CAS No.: 2818-64-6
• Molecular Formula: C9H8Cl2N2
• Molecular Weight: 215.082
• DSSTox Substance ID: DTXSID10357037
• Wikidata: Q82136728
• ChEMBL ID: CHEMBL227688
• Mol file: 2818-64-6.mol

Synonyms:5,6-dichloro-1,2-dimethylbenzimidazole;2818-64-6;5,6-dichloro-1,2-dimethyl-1H-benzimidazole;BAS 00004185;CHEMBL227688;SCHEMBL4882909;DTXSID10357037;ZLJHHGSEAITOGJ-UHFFFAOYSA-N;AKOS000547066;5,6-Dichloro-1,2-Dimethyl-Benzoimidazole;5,6-dichloro-1,2-dimethyl-1H-benzo[d]imidazole

Chemical Property of 5,6-Dichloro-1,2-dimethylbenzimidazole

Chemical Property:

• Vapor Pressure: 4.17E-05mmHg at 25°C
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 214.0064537
• Heavy Atom Count: 13
• Complexity: 200

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC2=CC(=C(C=C2N1C)Cl)Cl

Technology Process of 5,6-Dichloro-1,2-dimethylbenzimidazole

There total 4 articles about 5,6-Dichloro-1,2-dimethylbenzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5,6-dichloro-2-methylbenzimidazole (6478-79-1) + methyl iodide (74-88-4) → 5,6-dichloro-1,2-dimethyl-1H-benzimidazole (2818-64-6)

Guidance literature:

With potassium hydroxide; In acetone;

DOI:10.1021/ja063733d

Reference yield:

4,5-Dichloro-1,2-phenylenediamine (5348-42-5) + Triethyl orthoacetate (78-39-7) → 5,6-dichloro-1,2-dimethyl-1H-benzimidazole (2818-64-6)

Guidance literature:

toluene-4-sulfonic acid; In toluene;

Reference yield:

4,5-Dichloro-1,2-phenylenediamine (5348-42-5) → 5,6-dichloro-1,2-dimethyl-1H-benzimidazole (2818-64-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 5.7 g / p-toluenesulfonic acid / toluene / 3 h / Heating

2: 5.5 g / KOH / acetone

With potassium hydroxide; toluene-4-sulfonic acid; In acetone; toluene;

DOI:10.1021/ja063733d

upstream raw materials:

acetic anhydride

5,6-dichloro-2-methylbenzimidazole

methyl iodide

4,5-Dichloro-1,2-phenylenediamine