1,4-Piperidinedicarboxylic acid, 4-[[4-(2-butynyloxy)phenyl]sulfonyl]-, 1-(1,1-dimethylethyl) 4-methyl ester

Base Information

Chemical Name:1,4-Piperidinedicarboxylic acid, 4-[[4-(2-butynyloxy)phenyl]sulfonyl]-, 1-(1,1-dimethylethyl) 4-methyl ester
CAS No.:287202-48-6
Molecular Formula:C22H29NO7S
Molecular Weight:451.541
Hs Code.:

Synonyms:

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Chemical Property of 1,4-Piperidinedicarboxylic acid, 4-[[4-(2-butynyloxy)phenyl]sulfonyl]-, 1-(1,1-dimethylethyl) 4-methyl ester

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Technology Process of 1,4-Piperidinedicarboxylic acid, 4-[[4-(2-butynyloxy)phenyl]sulfonyl]-, 1-(1,1-dimethylethyl) 4-methyl ester

There total 3 articles about 1,4-Piperidinedicarboxylic acid, 4-[[4-(2-butynyloxy)phenyl]sulfonyl]-, 1-(1,1-dimethylethyl) 4-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 124443-68-1
1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate

: 287202-47-5
4-but-2-ynyloxy-benzenesulfonyl fluoride

: 287202-48-6
4-(4-but-2-ynyloxybenzenesulfonyl)-piperidine-1,4-dicarboxylic acid tert-butyl ester methyl ester

Guidance literature:: 1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.5h;

4-but-2-ynyloxy-benzenesulfonyl fluoride; In tetrahydrofuran; at 20 ℃; for 5h;
DOI:10.1016/S0040-4039(01)00835-8

Reference yield:

: 84358-13-4,174286-31-8
N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid

: 287202-48-6
4-(4-but-2-ynyloxybenzenesulfonyl)-piperidine-1,4-dicarboxylic acid tert-butyl ester methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 95 percent / K₂CO₃

2.1: LDA / tetrahydrofuran / 0.5 h / -78 °C

2.2: 85 percent / tetrahydrofuran / 5 h / 20 °C

With potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1016/S0040-4039(01)00835-8

Reference yield:

: 286459-94-7
4-but-2-ynyloxybenzenesulfonyl chloride

: 287202-48-6
4-(4-but-2-ynyloxybenzenesulfonyl)-piperidine-1,4-dicarboxylic acid tert-butyl ester methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: KF; CaF₂ / acetonitrile

2.1: LDA / tetrahydrofuran / 0.5 h / -78 °C

2.2: 85 percent / tetrahydrofuran / 5 h / 20 °C

With calcium fluoride; potassium fluoride; lithium diisopropyl amide; In tetrahydrofuran; acetonitrile;
DOI:10.1016/S0040-4039(01)00835-8