4-Acetamido-3-hydroxybiphenyl

Base Information

• Chemical Name: 4-Acetamido-3-hydroxybiphenyl
• CAS No.: 13347-44-9
• Molecular Formula: C₁₄H₁₃NO₂
• Molecular Weight: 227.263
• Hs Code.: 2924299090
• UNII: QLH93CV6N4
• DSSTox Substance ID: DTXSID901266199
• Nikkaji Number: J420.933H
• Wikidata: Q63088223
• ChEMBL ID: CHEMBL298508
• Mol file: 13347-44-9.mol

Synonyms:13347-44-9;N-(2-hydroxy-4-phenylphenyl)acetamide;4-Acetamido-3-hydroxybiphenyl;2'-Hydroxy-4'-phenylacetanilide;N-(3-Hydroxy(1,1'-biphenyl)-4-yl)acetamide;Acetanilide, 2'-hydroxy-4'-phenyl-;Acetamide, N-(3-hydroxy(1,1'-biphenyl)-4-yl)-;N-(3-Hydroxy(1,1/'-biphenyl)-4-yl)acetamide;N-(3-Hydroxy[1,1'-biphenyl]-4-yl)acetamide;Acetamide, N-(3-hydroxy[1,1'-biphenyl]-4-yl)-;CHEMBL298508;DTXSID901266199;N-(3-Hydroxy-1,1'-biphenyl-4-yl)acetamide;Q63088223

Chemical Property of 4-Acetamido-3-hydroxybiphenyl

Chemical Property:

• Boiling Point: 458.5oC at 760 mmHg
• Flash Point: 231.1oC
• PSA: 52.82000
• Density: 1.22g/cm3
• LogP: 3.66710
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 227.094628657
• Heavy Atom Count: 17
• Complexity: 261

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NC1=C(C=C(C=C1)C2=CC=CC=C2)O

Technology Process of 4-Acetamido-3-hydroxybiphenyl

There total 5 articles about 4-Acetamido-3-hydroxybiphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.3%

d(4)-methanol (811-98-3) + N-(Sulfonatooxy)-4-(acetylamino)biphenyl potassium salt → 2-Methyl-6-phenylbenzoxazole (61309-99-7) + N-Hydroxy-4-acetylaminonbiphenyl (4463-22-3) + 2-hydroxy-4-phenylacetanilide (13347-44-9) + C15H12(2)H3NO2 + C15H12(2)H3NO2 + C15H12(2)H3NO2

Guidance literature:

at 50 ℃; Rate constant; Mechanism;

DOI:10.1021/jo00079a028

Reference yield:

2-nitro 5-phenyl phenol (18062-89-0) → 2-hydroxy-4-phenylacetanilide (13347-44-9)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / 10percent Pd/C / tetrahydrofuran / 3 h / 2844.3 Torr / Ambient temperature

2: Et₃N / tetrahydrofuran / 0.25 h / Heating

With hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran;

DOI:10.1021/ja00074a010

Reference yield:

acetyl chloride (75-36-5) + 2-amino 5-phenyl phenol (4363-03-5,88847-42-1) → 2-hydroxy-4-phenylacetanilide (13347-44-9)

Guidance literature:

With triethylamine; In tetrahydrofuran; for 0.25h; Heating;

DOI:10.1021/ja00074a010

upstream raw materials:

d⁽⁴⁾-methanol

N-chloro-4-(acetylamino)biphenyl

acetyl chloride

2-amino 5-phenyl phenol