3-CYCLOPROPYLPHENOL

Base Information

• Chemical Name: 3-CYCLOPROPYLPHENOL
• CAS No.: 28857-88-7
• Molecular Formula: C9H10O
• Molecular Weight: 134.178
• Hs Code.: 2907199090
• Mol file: 28857-88-7.mol

Synonyms:m-Hydroxyphenylcyclopropan;3-cyclopropyl-phenol;m-Cyclopropylphenol;Phenol,3-cyclopropyl;

Chemical Property of 3-CYCLOPROPYLPHENOL

Chemical Property:

• Vapor Pressure: 0.017mmHg at 25°C
• Boiling Point: 246.611oC at 760 mmHg
• Flash Point: 118.866oC
• PSA: 20.23000
• Density: 1.158g/cm3
• LogP: 2.26960

Purity/Quality:

98%min ^*data from raw suppliers

3-cyclopropylphenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-CYCLOPROPYLPHENOL

There total 6 articles about 3-CYCLOPROPYLPHENOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

tert-butyl (3-cyclopropylphenoxy)dimethylsilane (1202643-51-3) → meta-cyclopropyl phenol (28857-88-7)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 0.5h;

Reference yield:

3-(4,5-dihydro-1H-pyrazol-3-yl)-phenol (28858-24-4) → meta-cyclopropyl phenol (28857-88-7)

Guidance literature:

With potassium hydroxide; platinum; at 120 - 180 ℃;

DOI:10.1007/BF00500684

Reference yield:

1-bromo-3-[(tert-butyldimethylsilyl)oxy]benzene (65423-56-5) → meta-cyclopropyl phenol (28857-88-7)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium phosphate; tricyclohexylphosphine; palladium diacetate / toluene; water / 110 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h

With potassium phosphate; tetrabutyl ammonium fluoride; palladium diacetate; tricyclohexylphosphine; In tetrahydrofuran; water; toluene;

upstream raw materials:

3-allylphenol

3-(4,5-dihydro-1H-pyrazol-3-yl)-phenol

1-allyl-3-methoxybenzene

tert-butyl (3-cyclopropylphenoxy)dimethylsilane

Refernces

• 1、 -. "HCV POLYMERASE INHIBITORS". Page/Page column 62. . Retrieved 2020/02/14.
• 2、 -. "HCV POLYMERASE INHIBITORS". Page/Page column 52; 53. . Retrieved 2015/03/28.