Carbamic acid, [2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy]-2-oxoethyl]-, phenylmethyl ester

Base Information

Chemical Name:Carbamic acid, [2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy]-2-oxoethyl]-, phenylmethyl ester
CAS No.:2899-58-3
Molecular Formula:C18H14N2O6
Molecular Weight:354.31400
Hs Code.:
Mol file:2899-58-3.mol

Synonyms:N-(Benzyloxycarbonylamino-acetoxy)-phthalimid;Benzyloxycarbonylamino-acetic acid 1,3-dioxo-1,3-dihydro-isoindol-2-yl ester;N-Benzyloxycarbonyl-glycyl-hydroxyphthalimid-ester;N-Benzyloxycarbonyl-glycin-(N-hydroxy-phthalimidester);Benzyloxycarbonyl-glycin-phthalimidyl-(2)-ester;Benzyloxycarbonyl-glycin-(N-hydroxy-phthalimid-ester);N-(N-benzyloxycarbonyl-glycyloxy)-phthalimide;

Suppliers and Price of Carbamic acid, [2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy]-2-oxoethyl]-, phenylmethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 5 raw suppliers

Chemical Property of Carbamic acid, [2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy]-2-oxoethyl]-, phenylmethyl ester

Chemical Property:

Melting Point:128 - 129 °C
PSA：102.01000
LogP:1.99600

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of Carbamic acid, [2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy]-2-oxoethyl]-, phenylmethyl ester

There total 4 articles about Carbamic acid, [2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy]-2-oxoethyl]-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1138-80-3
N-(Benzyloxycarbonyl)glycine

: 91837-50-2
N-trichloroacetoxyphthalimide

: 2899-58-3
1,3-dioxoisoindolin-2-yl ((benzyloxy)carbonyl)glycinate

Guidance literature:: With pyridine; In acetonitrile; at 22 - 23 ℃; for 12h; further solvents;
DOI:10.1007/BF00947860

Reference yield: 95.0%

: 524-38-9
N-hydroxyphthalimide

: 1138-80-3
N-(Benzyloxycarbonyl)glycine

: 2899-58-3
1,3-dioxoisoindolin-2-yl ((benzyloxy)carbonyl)glycinate

Guidance literature:: N-(Benzyloxycarbonyl)glycine; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

N-hydroxyphthalimide; In N,N-dimethyl-formamide; at 20 ℃; for 18h;
DOI:10.1021/acs.joc.0c01168

Reference yield:

: 524-38-9
N-hydroxyphthalimide

: 2899-58-3
1,3-dioxoisoindolin-2-yl ((benzyloxy)carbonyl)glycinate

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / ethyl acetate / 4 h / 70 - 72 °C

2: 100 percent / pyridine / acetonitrile / 12 h / 22 - 23 °C / further solvents

With pyridine; In ethyl acetate; acetonitrile;
DOI:10.1007/BF00947860