L-Proline, 1-((3,4-dichlorophenyl)methyl)-5-oxo-, methyl ester

Base Information

Chemical Name:L-Proline, 1-((3,4-dichlorophenyl)methyl)-5-oxo-, methyl ester
CAS No.:59749-19-8
Molecular Formula:C13H13Cl2NO3
Molecular Weight:302.157
Hs Code.:
DSSTox Substance ID:DTXSID60208464
Wikidata:Q76150751

Synonyms:N-(Dichloro-3',4' benzyl)pyroglutamate de methyle [French];L-Proline, 1-((3,4-dichlorophenyl)methyl)-5-oxo-, methyl ester;1-((3,4-Dichlorophenyl)methyl)-5-oxo-L-proline methyl ester;59749-19-8;N-(Dichloro-3',4' benzyl)pyroglutamate de methyle;DTXSID60208464;LS-118927

Suppliers and Price of L-Proline, 1-((3,4-dichlorophenyl)methyl)-5-oxo-, methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of L-Proline, 1-((3,4-dichlorophenyl)methyl)-5-oxo-, methyl ester

Chemical Property:

Vapor Pressure:2.48E-08mmHg at 25°C
Boiling Point:451.2°Cat760mmHg
Flash Point:226.7°C
Density:1.398g/cm³
XLogP3:2.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:301.0272487
Heavy Atom Count:19
Complexity:364

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)C1CCC(=O)N1CC2=CC(=C(C=C2)Cl)Cl
Isomeric SMILES:COC(=O)[C@@H]1CCC(=O)N1CC2=CC(=C(C=C2)Cl)Cl

Technology Process of L-Proline, 1-((3,4-dichlorophenyl)methyl)-5-oxo-, methyl ester

There total 1 articles about L-Proline, 1-((3,4-dichlorophenyl)methyl)-5-oxo-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 18880-04-1
3,4-dichlorobenzyl bromide

: 4931-66-2
methyl (S)-pyroglutamate

: 59749-19-8
C₁₃H₁₃Cl₂NO₃

Guidance literature:: methyl (S)-pyroglutamate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -20 ℃; for 1h; Inert atmosphere;

3,4-dichlorobenzyl bromide; In tetrahydrofuran; at 0 - 20 ℃; for 4h; Inert atmosphere;
DOI:10.1016/j.ejmech.2014.05.017

Reference yield:

: 59749-19-8
C₁₃H₁₃Cl₂NO₃

: 59749-23-4
(2S)-N-(3,4-dichloro-phenylmethyl)pyroglutamic acid

Guidance literature:: With water; sodium carbonate; In methanol; at 0 - 20 ℃; for 5h;
DOI:10.1016/j.ejmech.2014.05.017

Reference yield:

: 59749-19-8
C₁₃H₁₃Cl₂NO₃

: 1615249-89-2
tert-butyl ((S)-1-((S)-1-(3,4-dichlorobenzyl)-5-oxopyrrolidine-2-carbonyl)piperidin-3-yl)methylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium carbonate; water / methanol / 5 h / 0 - 20 °C

2.1: triethylamine / dichloromethane / 0.17 h / -20 °C / Inert atmosphere

2.2: 0.25 h / -20 °C / Inert atmosphere

2.3: 1.17 h / -20 - 20 °C / Inert atmosphere

With water; sodium carbonate; triethylamine; In methanol; dichloromethane;
DOI:10.1016/j.ejmech.2014.05.017