ethyl 7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-6-carboxylate

Base Information

• Chemical Name: ethyl 7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-6-carboxylate
• CAS No.: 29274-18-8
• Molecular Formula: C9H9N3O3
• Molecular Weight: 207.18600
• Hs Code.: 2933990090
• Mol file: 29274-18-8.mol

Synonyms:7-Oxo-6-aethoxycarbonyl-4,7-dihydro-pyrazolo<1,5-a>pyrimidin;

Chemical Property of ethyl 7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-6-carboxylate

Chemical Property:

• PSA: 76.46000
• LogP: 0.19930
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Ethyl7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-6-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-6-carboxylate

There total 4 articles about ethyl 7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3-aminopyrazole (1820-80-0,916420-28-5) + diethyl 2-ethoxymethylenemalonate (87-13-8) → ethyl 7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-6-carboxylate (29274-18-8)

Guidance literature:

With acetic acid; for 2h; Reflux;

DOI:10.1016/j.chembiol.2018.07.008

Reference yield: 58.0%

diethyl 2-((1H-pyrazol-5-ylamino)methylene)malonate (29274-17-7) → ethyl 7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-6-carboxylate (29274-18-8)

Guidance literature:

With diphenyl ether-biphenyl eutectic; at 250 ℃; for 2h;

Reference yield: 56.0%

3(5)-aminopyrazole (1225387-53-0) + diethyl 2-ethoxymethylenemalonate (87-13-8) → ethyl 7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-6-carboxylate (29274-18-8)

Guidance literature:

In acetic acid; at 120 ℃; for 4.5h;

DOI:10.1021/jo062120g

upstream raw materials:

3-aminopyrazole

diethyl 2-ethoxymethylenemalonate

3⁽⁵⁾-aminopyrazole

diethyl 2-((1H-pyrazol-5-ylamino)methylene)malonate

Downstream raw materials:

7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-6-carboxylic acid

7-chloropyrazolo[1,5-a]pyrirnidine

3-bromo-7-chloropyrazolo[1,5-a]pyrimidine

N-(2,4-di-tert-butyl-5-hydroxyphenyl)-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-6-carboxamide

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