N-(2-(5-Methyl-1,2,4-oxadiazol-3-yl)phenyl)acetamide

Base Information

• Chemical Name: N-(2-(5-Methyl-1,2,4-oxadiazol-3-yl)phenyl)acetamide
• CAS No.: 29368-92-1
• Molecular Formula: C11H11N3O2
• Molecular Weight: 217.227
• DSSTox Substance ID: DTXSID50512784
• Wikidata: Q82372180
• Mol file: 29368-92-1.mol

Synonyms:29368-92-1;N-(2-(5-Methyl-1,2,4-oxadiazol-3-yl)phenyl)acetamide;N-[2-(5-Methyl-1,2,4-oxadiazol-3-yl)phenyl]acetamide;Acetamide, N-[2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-;3-(2-Acetamidophenyl)-5-methyl-1,2,4-oxadiazole;DTXSID50512784

Chemical Property of N-(2-(5-Methyl-1,2,4-oxadiazol-3-yl)phenyl)acetamide

Chemical Property:

• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 217.085126602
• Heavy Atom Count: 16
• Complexity: 260

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC(=NO1)C2=CC=CC=C2NC(=O)C

Technology Process of N-(2-(5-Methyl-1,2,4-oxadiazol-3-yl)phenyl)acetamide

There total 5 articles about N-(2-(5-Methyl-1,2,4-oxadiazol-3-yl)phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

N-acetoxy-2-acetylamino-benzamidine (29368-89-6) → N-[2-(5-methyl-[1,2,4]oxadiazol-3-yl)-phenyl]-acetamide (29368-92-1)

Guidance literature:

With sodium carbonate; In acetone; for 2h; Ambient temperature;

Reference yield:

2-amino-N’-hydroxybenzimidamide (16348-49-5) → N-[2-(5-methyl-[1,2,4]oxadiazol-3-yl)-phenyl]-acetamide (29368-92-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / sodium ethoxide / ethanol / 8 h / Heating

2: 74 percent

With sodium ethanolate; In ethanol;

Reference yield:

o-nitrobenzonitrile (612-24-8) → N-[2-(5-methyl-[1,2,4]oxadiazol-3-yl)-phenyl]-acetamide (29368-92-1)

Guidance literature:

Multi-step reaction with 3 steps

1: tin dichloride; hydrochloric acid

2: alcohol; water; sodium; hydroxylamine hydrochloride / 100 °C

3: 130 - 140 °C

With hydrogenchloride; ethanol; hydroxylamine hydrochloride; water; sodium; tin(ll) chloride;

upstream raw materials:

2-amino-N’-hydroxybenzimidamide

acetic anhydride

N-acetoxy-2-acetylamino-benzamidine

o-nitrobenzonitrile

Downstream raw materials:

3-(2-aminophenyl)-5-methyl-1,2,4-oxadiazole