16348-49-5

Usage

Uses

Used in Biochemical Research:
2-Amino-N-hydroxy-benzamidine is used as a research tool for studying the function and inhibition of serine protease enzymes. Its ability to inhibit these enzymes aids in understanding their role in various biological processes and disease mechanisms.
Used in Drug Development:
2-AMINO-N-HYDROXY-BENZAMIDINE serves as a key component in the development of new drugs targeting serine protease enzymes. Its potent inhibitory properties make it a valuable starting point for designing therapeutic agents to treat diseases associated with these enzymes.
Used in Pharmaceutical Synthesis:
2-Amino-N-hydroxy-benzamidine is used as a versatile building block in the synthesis of various pharmaceuticals and biologically active compounds. Its unique structure allows for the creation of novel molecules with potential therapeutic applications.
Used in Medical Applications:
2-Amino-N-hydroxy-benzamidine has been studied for its potential applications in treating diseases such as cancer, inflammation, and cardiovascular disorders. Its anticoagulant and antithrombotic properties make it a promising candidate for the development of treatments targeting these conditions.
Used in the Development of Anticancer Agents:
2-AMINO-N-HYDROXY-BENZAMIDINE is being investigated for its potential as an anticancer agent, with its ability to inhibit serine protease enzymes playing a crucial role in the regulation of tumor growth and progression.
Used in the Development of Anti-inflammatory Agents:
2-Amino-N-hydroxy-benzamidine's potential to modulate serine protease enzymes involved in inflammation makes it a candidate for the development of anti-inflammatory drugs.
Used in the Development of Cardiovascular Agents:
Given its anticoagulant and antithrombotic properties, the compound is being explored for its potential in developing treatments for cardiovascular disorders, where modulation of serine protease enzymes could be beneficial in managing clot formation and related complications.

InChI:InChI=1/C7H9N3O/c8-6-4-2-1-3-5(6)7(9)10-11/h1-4,11H,8H2,(H2,9,10)

Upstream product

• 1885-29-6 anthranilic acid nitrile 
• 29083-68-9 3-oxy-2-propyl-1,2-dihydro-quinazolin-4-ylamine 
• 7803-49-8 hydroxylamine 
• 612-24-8 o-nitrobenzonitrile 
• 108732-43-0 2-Methyl-3-oxy-1,2-dihydro-quinazolin-4-ylamine 

Downstream Products

• 29368-94-3 3-(2-aminophenyl)-5-methyl-1,2,4-oxadiazole 
• 29368-92-1 N-[2-(5-methyl-[1,2,4]oxadiazol-3-yl)-phenyl]-acetamide 
• 29083-74-7 3,5-bis-(4-methoxy-phenyl)-5,6-dihydro-[1,2,4]oxadiazolo[4,3-c]quinazoline 
• 108732-42-9 (E)-4-amino-2-styryl-1,2-dihydroquinazoline 3-oxide 
• 94079-17-1 3-(2-Aminophenyl)-5-(2-piperidinoethyl)-1,2,4-oxadiazol 
• 82216-53-3 2-(5-p-Tolyl-[1,2,4]oxadiazol-3-yl)-phenylamine 
• 94079-15-9 3-(2-Aminophenyl)-5-(diphenylmethyl)-1,2,4-oxadiazol 
• 29083-89-4 3-(2-aminophenyl)-5-phenyl-1,2,4-oxadiazole 
• 82216-55-5 2-[5-(4-Nitro-phenyl)-[1,2,4]oxadiazol-3-yl]-phenylamine 
• 82216-58-8 2-[5-(2,2-Diphenyl-ethyl)-[1,2,4]oxadiazol-3-yl]-phenylamine 
• 82216-54-4 2-[5-(4-Chloro-phenyl)-[1,2,4]oxadiazol-3-yl]-phenylamine 
• 94079-14-8 3-(2-Aminophenyl)-5-(4-methoxyphenyl)-1,2,4-oxadiazol 
• 108732-40-7 3-Oxy-2-p-tolyl-1,2-dihydro-quinazolin-4-ylamine 
• 16348-24-6 1,2-dihydro-2-phenyl-4(3H)-guinazolone oxime 

Relevant academic research and scientific papers

A Kinetic Photometric Assay for the Quantification of the Open-Chain Content of Aldoses

Aldoses exist predominantly in the cyclic hemiacetal form, which is in equilibrium with the open-chain aldehyde form. The small aldehyde content hampers reactivity when chemistry addresses the carbonyl moiety. This low concentration of the available aldeh

1,2-Dihydro-4-quinazolinamines: Potent, highly selective inhibitors of inducible nitric oxide synthase which show antiinflammatory activity in vivo

The discovery of a novel class of nitric oxide synthase (NOS) inhibitors, 2-substituted 1,2-dihydro-4-quinazolinamines, and the related 4′-aminospiro[piperidine-4,2′(1′H)-quinazolin]- 4′-amines is described. Members of both series exhibit nanomolar potenc

Construction of Bicyclic 1,2,3-Triazine N-Oxides from Aminocyanides

Using a facile and cost-effective method, nine bicyclic 1,2,3-triazine 2-oxides were synthesized from o-aminocyanide substrates through an unusual nitration cyclization. The reaction mechanism was studied experimentally and theoretically. Moreover, nine 1

Imidazole hydrochloride promoted synthesis of 3,5-disubstituted-1,2,4-oxadiazoles

Imidazole hydrochloride as an additive promotes the reaction of amidoximes and DMA derivatives to generated 3,5-disubstituted-1,2,4-oxadiazoles in low to excellent yields without the use of coupling reagents, oxidants, strong acids or bases and other additives.

Substrate-Independent High-Throughput Assay for the Quantification of Aldehydes

The selective and direct reduction of carboxylic acids into the corresponding aldehydes by chemical methods is still a challenging task in synthesis. Several reductive and oxidative chemical methods are known to produce aldehydes, but most of them require

Practical synthesis of N -substituted cyanamides via tiemann rearrangement of amidoximes

A facile and general synthesis of various N-substituted cyanamides was accomplished by the Tiemann rearrangement of amidoximes with benzenesulfonyl chlorides (TsCl or o-NsCl) and DIPEA.

Synthetic studies toward 3-(acylamino)-1 H-indazoles and development of a one-pot, microwave-assisted, oxadiazole condensation/Boulton-Katritzky rearrangement

Studies on the Boulton-Katritzky rearrangement of 3-(2-aminoaryl)-1,2,4- oxadiazoles have led to the identification of additional electronic factors that govern the rearrangement as well as a competitive thermal rearrangement pathway for select substrates

STABILIZATION OF HYDROXYLAMINE CONTAINING SOLUTIONS AND METHOD FOR THEIR PREPARATION

The invention relates to the use of amidoximes for prevention of or stabilization of hydroxylamine compounds against undesired decomposition.

INDAZOLE DERIVATIVES WHICH INTERACT WITH THE G-PROTEIN COUPLED RECEPTOR FAMILY

Compounds of the general formula: (I) wherein Y, R and R’ are as described in the specification. Further included are pharmaceutical compositions comprising the compounds, processes for their preparation, as well as the use of the compounds for the prepar

A New type of Dimroth Rearrangement: Formation of 1,2-Dihydro-3H-quinazolone 4-Oximes from 4-Amino-1,2-dihydroquinazoline 3-Oxides

Contrary to earlier claims the primary product of the reaction of aldehydes and o-aminobenzamide oxime is, irrespective of the aldehyde, always a 4-amino-1,2-dihydroquinazoline 3-oxide.Thermolysis of 1-unsubstituted 2-substituted quinazoline 3-oxides (5) in solution or in melt gives rise, by a new type of Dimroth rearrangement, to the isomeric 1,2-dihydro-4-quinazolone oximes (6), while the 1-benzyl 2-unsubstituted analogue (9j) yields, presumably by an addition-elimination ring transformation coupled with oxidation, a quinoidal quinazolone 4-oxime (17).