1-Bromo-2,4-bis(methoxymethoxy)benzene

Base Information

• Chemical Name: 1-Bromo-2,4-bis(methoxymethoxy)benzene
• CAS No.: 295788-93-1
• Molecular Formula: C10H13BrO4
• Molecular Weight: 277.115
• DSSTox Substance ID: DTXSID90464495
• Nikkaji Number: J1.945.559I
• Wikidata: Q82289833
• Mol file: 295788-93-1.mol

Synonyms:1-bromo-2,4-bis(methoxymethoxy)benzene;295788-93-1;Benzene, 1-bromo-2,4-bis(methoxymethoxy)-;1,3-Bis(methoxymethoxy)-4-bromobenzene;SCHEMBL614591;DTXSID90464495;RBEZSHBGSUCUAJ-UHFFFAOYSA-N;1-bromo-2,4-bismethoxymethoxybenzene;1-bromo-2,4-bis(methoxy-methoxy)benzene;FT-0736100

Chemical Property of 1-Bromo-2,4-bis(methoxymethoxy)benzene

Chemical Property:

• XLogP3: 2.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 275.99972
• Heavy Atom Count: 15
• Complexity: 168

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCOC1=CC(=C(C=C1)Br)OCOC

Technology Process of 1-Bromo-2,4-bis(methoxymethoxy)benzene

There total 3 articles about 1-Bromo-2,4-bis(methoxymethoxy)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-Bromoresorcinol (6626-15-9) + chloromethyl methyl ether (107-30-2) → 1-bromo-2,4-bis(methoxymethoxy)benzene (295788-93-1)

Guidance literature:

4-Bromoresorcinol; With potassium carbonate; In acetone; at 5 ℃; for 0.166667h;

chloromethyl methyl ether; In acetone; at 20 ℃;

Reference yield: 89.0%

4-Bromoresorcinol (6626-15-9) + (methoxymethoxy)methyl chloride (122776-88-9) → 1-bromo-2,4-bis(methoxymethoxy)benzene (295788-93-1)

Guidance literature:

4-Bromoresorcinol; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.5h;

(methoxymethoxy)methyl chloride; With tetra-(n-butyl)ammonium iodide; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 2h;

DOI:10.1016/j.tetlet.2015.06.075

Reference yield:

CH2CI2 + 4-Bromoresorcinol (6626-15-9) + chloromethyl methyl ether (107-30-2) → 1-bromo-2,4-bis(methoxymethoxy)benzene (295788-93-1)

Guidance literature:

With diisopropylamine;

upstream raw materials:

4-Bromoresorcinol

chloromethyl methyl ether

(methoxymethoxy)methyl chloride

Downstream raw materials:

1-(2,4-bis-methoxymethoxy-phenyl)-3-(3-{4-[3-(2,4-bis-methoxymethoxy-phenyl)-3-hydroxy-propyl]-2-methoxy-phenoxy}-4-methoxymethoxy-phenyl)-propan-1-ol

1-(2,4-bis-methoxymethoxy-phenyl)-3-(3-{4-[3-(2,4-bis-methoxymethoxy-phenyl)-3-oxo-propyl]-phenoxy}-4-methoxymethoxy-phenyl)-propan-1-one

1-(2,4-bis-methoxymethoxy-phenyl)-3-(4-{5-[3-(2,4-bis-methoxymethoxy-phenyl)-3-oxo-propyl]-3-chloro-2-methoxymethoxy-phenoxy}-3-chloro-5-methoxy-phenyl)-propan-1-one

2,4-bis(methoxymethoxy)phenylboronic acid