1-(2,4-bis-methoxymethoxy-phenyl)-3-(3-{4-[3-(2,4-bis-methoxymethoxy-phenyl)-3-hydroxy-propyl]-2-methoxy-phenoxy}-4-methoxymethoxy-phenyl)-propan-1-ol

Base Information

Chemical Name:1-(2,4-bis-methoxymethoxy-phenyl)-3-(3-{4-[3-(2,4-bis-methoxymethoxy-phenyl)-3-hydroxy-propyl]-2-methoxy-phenoxy}-4-methoxymethoxy-phenyl)-propan-1-ol
CAS No.:704912-95-8
Molecular Formula:C₄₁H₅₂O₁₄
Molecular Weight:768.855
Hs Code.:

1-(2,4-bis-methoxymethoxy-phenyl)-3-(3-{4-[3-(2,4-bis-methoxymethoxy-phenyl)-3-hydroxy-propyl]-2-methoxy-phenoxy}-4-methoxymethoxy-phenyl)-propan-1-ol

Synonyms:1-(2,4-bis-methoxymethoxy-phenyl)-3-(3-{4-[3-(2,4-bis-methoxymethoxy-phenyl)-3-hydroxy-propyl]-2-methoxy-phenoxy}-4-methoxymethoxy-phenyl)-propan-1-ol

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Chemical Property of 1-(2,4-bis-methoxymethoxy-phenyl)-3-(3-{4-[3-(2,4-bis-methoxymethoxy-phenyl)-3-hydroxy-propyl]-2-methoxy-phenoxy}-4-methoxymethoxy-phenyl)-propan-1-ol

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Technology Process of 1-(2,4-bis-methoxymethoxy-phenyl)-3-(3-{4-[3-(2,4-bis-methoxymethoxy-phenyl)-3-hydroxy-propyl]-2-methoxy-phenoxy}-4-methoxymethoxy-phenyl)-propan-1-ol

There total 11 articles about 1-(2,4-bis-methoxymethoxy-phenyl)-3-(3-{4-[3-(2,4-bis-methoxymethoxy-phenyl)-3-hydroxy-propyl]-2-methoxy-phenoxy}-4-methoxymethoxy-phenyl)-propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 295788-93-1
1-bromo-2,4-bis(methoxymethoxy)benzene

: 704912-94-7
3-[3-methoxy-4-(2-(methoxymethoxy)-5-(3-oxopropyl)phenoxy)phenyl]propanal

: 704912-95-8
1-(2,4-bis-methoxymethoxy-phenyl)-3-(3-{4-[3-(2,4-bis-methoxymethoxy-phenyl)-3-hydroxy-propyl]-2-methoxy-phenoxy}-4-methoxymethoxy-phenyl)-propan-1-ol

Guidance literature:: With n-butyllithium; In tetrahydrofuran;
DOI:10.1016/j.tetlet.2004.02.154

Reference yield:

: 80373-18-8
3-(4'-hydroxyphenyl)-1-propyl acetate

: 704912-95-8
1-(2,4-bis-methoxymethoxy-phenyl)-3-(3-{4-[3-(2,4-bis-methoxymethoxy-phenyl)-3-hydroxy-propyl]-2-methoxy-phenoxy}-4-methoxymethoxy-phenyl)-propan-1-ol

Guidance literature:: Multi-step reaction with 12 steps

1.1: SO₂Cl₂ / CHCl₃

1.2: HBr₃*pyriidne

2.1: 3 percent / methanol; pyridine / Electrochemical reaction

3.1: 79 percent / Zn*AcOH / tetrahydrofuran

4.1: 100 percent / Huenig base / CH₂Cl₂

5.1: 100 percent / K₂CO₃ / methanol

6.1: 100 percent / imidazole

7.1: B(OMe)3; n-BuLi

7.2: 82 percent / aq. NaOH; H₂O₂

8.1: 100 percent / K₂CO₃ / dimethylformamide

9.1: 84 percent / HCO₂NH₄ / Pd/C / ethanol / 60 °C

10.1: 100 percent / TBAF / tetrahydrofuran

11.1: 81 percent / CH₂Cl₂

12.1: 27 percent / n-BuLi / tetrahydrofuran

With 1H-imidazole; n-butyllithium; sulfuryl dichloride; Trimethyl borate; tetrabutyl ammonium fluoride; ammonium formate; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide; 11.1: Dess-Martin oxidation;
DOI:10.1016/j.tetlet.2004.02.154

Reference yield:

: 704912-87-8
3-(5-bromo-3-chloro-4-hydroxyphenyl)propyl acetate

: 704912-95-8
1-(2,4-bis-methoxymethoxy-phenyl)-3-(3-{4-[3-(2,4-bis-methoxymethoxy-phenyl)-3-hydroxy-propyl]-2-methoxy-phenoxy}-4-methoxymethoxy-phenyl)-propan-1-ol

Guidance literature:: Multi-step reaction with 11 steps

1.1: 3 percent / methanol; pyridine / Electrochemical reaction

2.1: 79 percent / Zn*AcOH / tetrahydrofuran

3.1: 100 percent / Huenig base / CH₂Cl₂

4.1: 100 percent / K₂CO₃ / methanol

5.1: 100 percent / imidazole

6.1: B(OMe)3; n-BuLi

6.2: 82 percent / aq. NaOH; H₂O₂

7.1: 100 percent / K₂CO₃ / dimethylformamide

8.1: 84 percent / HCO₂NH₄ / Pd/C / ethanol / 60 °C

9.1: 100 percent / TBAF / tetrahydrofuran

10.1: 81 percent / CH₂Cl₂

11.1: 27 percent / n-BuLi / tetrahydrofuran

With 1H-imidazole; n-butyllithium; Trimethyl borate; tetrabutyl ammonium fluoride; ammonium formate; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; 10.1: Dess-Martin oxidation;
DOI:10.1016/j.tetlet.2004.02.154