2-((3-Cyano-6-(2-thienyl)-4-(trifluoromethyl)-2-pyridinyl)thio)acetamide

Base Information

Chemical Name:2-((3-Cyano-6-(2-thienyl)-4-(trifluoromethyl)-2-pyridinyl)thio)acetamide
CAS No.:299198-19-9
Molecular Formula:C13H8F3N3OS2
Molecular Weight:343.34700
Hs Code.:
European Community (EC) Number:649-029-6
Mol file:299198-19-9.mol

Synonyms:STK870588;AKOS000575268;SR-01000507179;SR-01000507179-1;Z92722153;2-((3-CYANO-6-(2-THIENYL)-4-(TRIFLUOROMETHYL)-2-PYRIDINYL)THIO)ACETAMIDE;2-{[3-cyano-6-(thiophen-2-yl)-4-(trifluoromethyl)pyridin-2-yl]sulfanyl}acetamide

Suppliers and Price of 2-((3-Cyano-6-(2-thienyl)-4-(trifluoromethyl)-2-pyridinyl)thio)acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
2-((3-CYANO-6-(2-THIENYL)-4-(TRIFLUOROMETHYL)-2-PYRIDINYL)THIO)ACETAMIDE 95.00%
5MG
$ 498.44

Total 0 raw suppliers

Chemical Property of 2-((3-Cyano-6-(2-thienyl)-4-(trifluoromethyl)-2-pyridinyl)thio)acetamide

Chemical Property:

Melting Point:237 - 238 °C (ethanol)
Boiling Point:531.1±50.0 °C(Predicted)
PKA:15.03±0.40(Predicted)
PSA：133.31000
Density:1.54±0.1 g/cm3(Predicted)
LogP:3.97828
XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:4
Exact Mass:343.00608872
Heavy Atom Count:22
Complexity:465

Purity/Quality:: 2-((3-CYANO-6-(2-THIENYL)-4-(TRIFLUOROMETHYL)-2-PYRIDINYL)THIO)ACETAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CSC(=C1)C2=NC(=C(C(=C2)C(F)(F)F)C#N)SCC(=O)N

Technology Process of 2-((3-Cyano-6-(2-thienyl)-4-(trifluoromethyl)-2-pyridinyl)thio)acetamide

There total 2 articles about 2-((3-Cyano-6-(2-thienyl)-4-(trifluoromethyl)-2-pyridinyl)thio)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 104960-50-1
4-(trifluoromethyl)-1,2-dihydro-6-(thiophen-2-yl)-2-thioxopyridine-3-carbonitrile

: 79-07-2
Chloroacetamide

: 299198-19-9
3-cyano-6-(2-thienyl)-4-trifluoromethylpyridin-2-ylthioacetamide

Guidance literature:: With sodium acetate; In ethanol; for 0.5h; Heating;

Reference yield:

: 326-91-0
1,1,1-trifluoro-4-(2-thienyl)butane-2,4-dione

: 299198-19-9
3-cyano-6-(2-thienyl)-4-trifluoromethylpyridin-2-ylthioacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / NEt₃ / ethanol / 2 h / Heating

2: 79 percent / NaOAc*3H₂O / ethanol / 4 h / Heating

With sodium acetate; triethylamine; In ethanol;

Reference yield:

: 299198-19-9
3-cyano-6-(2-thienyl)-4-trifluoromethylpyridin-2-ylthioacetamide

: 331466-74-1
2-phenyl-7-(thiophen-2-yl)-9-(trifluoromethyl)-2,3-dihydropyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / K₂CO₃ / ethanol / 3 h / Heating

2: 82 percent / acetic acid / 4 h / Heating

With potassium carbonate; In ethanol; acetic acid; 1: Thorpe-Ziegler cyclization;