N-methyl-5-phenyl-1H-pyrazol-3-amine

Base Information

• Chemical Name: N-methyl-5-phenyl-1H-pyrazol-3-amine
• CAS No.: 30120-58-2
• Molecular Formula: C10H11N3
• Molecular Weight: 173.217
• European Community (EC) Number: 841-698-4
• Nikkaji Number: J1.916.035A
• Mol file: 30120-58-2.mol

Synonyms:N-methyl-5-phenyl-1H-pyrazol-3-amine;30120-58-2;5-methylamino-3-phenylpyrazole;SCHEMBL4948626;3-methylamino-5-phenyl-pyrazole;SCHEMBL18366399;AKOS011839167;AKOS022477595;EN300-65703;A1-08821;Z1021411592

Chemical Property of N-methyl-5-phenyl-1H-pyrazol-3-amine

Chemical Property:

• XLogP3: 2.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 173.095297364
• Heavy Atom Count: 13
• Complexity: 154

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CNC1=NNC(=C1)C2=CC=CC=C2

Technology Process of N-methyl-5-phenyl-1H-pyrazol-3-amine

There total 11 articles about N-methyl-5-phenyl-1H-pyrazol-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-Methyl-6-nitro-2-phenyl-4H-pyrazolo[1,5-a]pyrimidin-7-one (137811-88-2) → 5-methylamino-3-phenylpyrazole (30120-58-2) + 4-nitro-3-pyrazolone hydrazinium salt (137811-92-8)

Guidance literature:

With hydrazine hydrate; In isopropyl alcohol; for 0.5h; Heating;

DOI:10.1007/BF00474001

Reference yield: 93.0%

3-methylamino-3-methylthio-1-phenylprop-2-en-1-one (91787-80-3) → N-methyl-5-phenyl-1H-pyrazol-3-amine (30120-58-2)

Guidance literature:

With hydrazine hydrate; In ethanol; for 8h; Heating;

Reference yield: 54.0%

(E)-3-Ethoxy-3-methylamino-1-phenyl-propenone (200862-22-2) → 5-methylamino-3-phenylpyrazole (30120-58-2)

Guidance literature:

With montmorillonite K-10; hydrazine hydrate; In dichloromethane; for 22h; ultrasound bath;

DOI:10.1055/s-2003-39398

upstream raw materials:

3-methylamino-3-methylthio-1-phenylprop-2-en-1-one

N-methyl-5-phenyl-6H-1,3,4-thiadiazin-2-amine

4-Methyl-6-nitro-2-phenyl-4H-pyrazolo[1,5-a]pyrimidin-7-one

methylamine

Downstream raw materials:

3-phenyl-5-benzyl-7-methyl-4,5,6,7-tetrahydro-1(2H)-pyrazolo<3,4-d>pyrimidine

5,7-Dimethyl-3-phenyl-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-d]pyrimidine

7-Methyl-3,5-diphenyl-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-d]pyrimidine

5-Ethyl-7-methyl-3-phenyl-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-d]pyrimidine