200862-22-2Relevant academic research and scientific papers
Efficient regiocontrolled synthesis and antimicrobial activity of pyrazoles
Braibante, Mara E. F.,Braibante, Hugo T. S.,Tavares, Luciana De Carvalho,Rohte, Simone F.,Costa, Carla C.,Morel, Ademir F.,Stueker, Caroline Z.,Burrow, Robert A.
, p. 2485 - 2490 (2008/02/13)
A series of 1,5-diphenyl-1H-pyrazol-3-amines, 3-ethoxy-5-phenyl-1H- pyrazole, 5-ethoxy-1,3-diphenyl-1H-pyrazole and 3-ethoxy-1,5-diphenyl-1H- pyrazole were efficiently prepared from the regiocontrolled cyclization of α-oxoketene O,N-acetals and/or β-oxo thioxoesters with hydrazine derivatives using montmorillonite K-10 as solid support with ultrasound. The antimicrobial activity of the heterocyclic compounds was evaluated by direct bioautography test. Georg Thieme Verlag Stuttgart.
Synthesis of aminopyrazoles from α- oxoketene O,N-acetals using Montmorillonite K-10/Ultrasound
Braibante, Mara E. F.,Braibante, Hugo T. S.,Da Roza, Juliano K.,Henriques, Danielle M.,De Carvalho Tavares, Luciana
, p. 1160 - 1162 (2007/10/03)
5(3)-Amino-3(5) phenylpyrazoles 3a-f have been conveniently prepared by condensation of α-oxoketene O,N-acetals 2a-g with hydrazine using montmorillonite K-10 as solid support under sonication.
Mild synthesis of α-oxoketene O,N-acetals from β-oxothioxo esters and amines
Furukawa, Isao,Fujisawa, Hironori,Abe, Tetsuji,Ohta, Tetsuo
, p. 599 - 606 (2007/10/03)
α-Oxoketene O,N-acetals were prepared from β-oxothiono esters and primary amines in the presence of Methylamine at room temperature within several hours in good yields.
A new two-step synthesis of α-oxoketene O,N-acetals
Moussounga,Bouquant,Chuche
, p. 483 - 485 (2007/10/02)
A new synthesis of α-oxoketene O,N-acetals has been developed from β-oxothioxo esters. Thus, the reaction of 2a-c with alkyl, allyl or cyclic primary amines in refluxing toluene and formic acid led to α-oxoketene O,N-acetals 3a-i in good yields.
