Benzene, 1-chloro-2-methoxy-5-methyl-3-nitro-

Base Information

• Chemical Name: Benzene, 1-chloro-2-methoxy-5-methyl-3-nitro-
• CAS No.: 30435-35-9
• Molecular Formula: C8H8ClNO3
• Molecular Weight: 201.609
• Mol file: 30435-35-9.mol

Synonyms:3-Chloro-4-methoxy-5-nitrotoluol;5-Chlor-3-nitro-4-methoxy-1-methyl-benzol;2-Chlor-4-methyl-6-nitro-anisol;2-chloro-4-methyl-6-nitro-anisole;2-cloro-4-methyl-6-nitroanisole;Methyl-(6-chlor-2-nitro-4-methyl-phenyl)-aether;

Chemical Property of Benzene, 1-chloro-2-methoxy-5-methyl-3-nitro-

Chemical Property:

• PSA: 55.05000
• LogP: 3.08840

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzene, 1-chloro-2-methoxy-5-methyl-3-nitro-

There total 7 articles about Benzene, 1-chloro-2-methoxy-5-methyl-3-nitro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.4%

2-chloro-1-methoxy-4-methylbenzene (22002-44-4) → 2-chloro-4-methyl-6-nitroanisole (30435-35-9) + 2-chloro-p-cresol (6640-27-3) + 2-chloro-4-methyl-6-nitrophenol (60468-61-3)

Guidance literature:

With nitric acid; In sulfuric acid; at 25 ℃; Rate constant; Product distribution; various acid concentrations and molar ratios;

DOI:10.1039/P29830000075

Reference yield:

2-chloro-4-methyl-6-nitrophenol (60468-61-3) + dimethyl sulfate (77-78-1) → 2-chloro-4-methyl-6-nitroanisole (30435-35-9)

Guidance literature:

With sodium carbonate; In toluene;

Reference yield:

2-chloro-p-cresol (6640-27-3) → 2-chloro-4-methyl-6-nitroanisole (30435-35-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / aq. NaOH / 3 h / Heating

2: 33 percent Spectr_. / nitric acid, Ac₂O / 1.) -78 deg C; 2.) -40 deg C, 1 h

With sodium hydroxide; nitric acid; acetic anhydride;

upstream raw materials:

2-chloro-1-methoxy-4-methylbenzene

acetic anhydride

2-chloro-4-methyl-6-nitrophenol

dimethyl sulfate

Downstream raw materials:

3-chloro-2-methoxy-5-methylaniline