3-CHLORO-4-METHOXYTOLUENE

Base Information

• Chemical Name: 3-CHLORO-4-METHOXYTOLUENE
• CAS No.: 22002-44-4
• Molecular Formula: C8H9 Cl O
• Molecular Weight: 156.612
• Hs Code.: 2909309090
• Mol file: 22002-44-4.mol

Synonyms:Anisole,2-chloro-4-methyl- (8CI); 2-Chloro-1-methoxy-4-methylbenzene;2-Chloro-4-methylanisole; 3-Chloro-4-methoxytoluene

Chemical Property of 3-CHLORO-4-METHOXYTOLUENE

Chemical Property:

• Vapor Pressure: 0.279mmHg at 25°C
• Boiling Point: 210.4°Cat760mmHg
• Flash Point: 86.9°C
• PSA: 9.23000
• Density: 1.105g/cm³
• LogP: 2.65700

Purity/Quality:

97% ^*data from raw suppliers

3-Chloro-4-methoxytoluene ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38-41
• Safety Statements: 26-36/37/39-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-CHLORO-4-METHOXYTOLUENE

There total 14 articles about 3-CHLORO-4-METHOXYTOLUENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-chloro-p-cresol (6640-27-3) + dimethyl sulfate (77-78-1) → 2-chloro-1-methoxy-4-methylbenzene (22002-44-4)

Guidance literature:

With sodium hydroxide; for 3h; Heating;

Reference yield: 87.0%

p-methylanizole (104-93-8) → 2-chloro-1-methoxy-4-methylbenzene (22002-44-4)

Guidance literature:

With calcium hypochlorite; In water; acetic acid; acetone; at 0 ℃; for 1h;

Reference yield: 80.0%

2,4-Xylenol (105-67-9) + methyl iodide (74-88-4) → 2-chloro-1-methoxy-4-methylbenzene (22002-44-4)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 3h; Schlenk technique; Inert atmosphere; Green chemistry;

DOI:10.1002/chem.202005158

upstream raw materials:

p-methylanizole

Cresidine

sodium acetate

2-chloro-p-cresol

Downstream raw materials:

3-chloro-4-methoxy benzoic acid

2-chloro-4-methyl-6-nitroanisole

2-chloro-4-methyl-6-nitrophenol

2-chloro-4-methyl-4-nitrocyclohexa-2,5-dienone