Lodal

Base Information

• Chemical Name: Lodal
• CAS No.: 553-28-6
• Molecular Formula: C12H16 N O2 . Cl
• Molecular Weight: 241.718
• Hs Code.: 2933499090
• European Community (EC) Number: 209-037-9
• NSC Number: 33525
• DSSTox Substance ID: DTXSID60970619
• Mol file: 553-28-6.mol

Synonyms:Lodal;553-28-6;EINECS 209-037-9;NSC 33525;3,4-Dihydro-6,7-dimethoxy-2-methylisoquinolinium chloride;6,7-dimethoxy-2-methyl-3,4-dihydroisoquinolin-2-ium chloride;ISOQUINOLINIUM, 3,4-DIHYDRO-6,7-DIMETHOXY-2-METHYL-, CHLORIDE;C12H16NO2.Cl;C12-H16-N-O2.Cl;DTXSID60970619;NSC33525;NSC-33525;LS-86076;Isoquinolinium,4-dihydro-6,7-dimethoxy-2-methyl-, chloride

Chemical Property of Lodal

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 21.47000
• Density: g/cm³
• LogP: -1.71610
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 241.0869564
• Heavy Atom Count: 16
• Complexity: 252

Purity/Quality:

99% ^*data from raw suppliers

3,4-DIHYDRO-6,7-DIMETHOXY-2-METHYLISOQUINOLINIUM CHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C[N+]1=CC2=CC(=C(C=C2CC1)OC)OC.[Cl-]

Technology Process of Lodal

There total 5 articles about Lodal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-methylhomoveratrylamine (3490-06-0) + formic acid (64-18-6) → 6,7-dimethoxy-2-methyl-3,4-dihydro-isoquinolinium; chloride (553-28-6)

Guidance literature:

at 210 ℃; Erwaermen des Reaktionsprodukts in Benzol mit Thionylchlorid und Erhitzen des erhaltenen kristallinen Reaktionsprodukts auf 140grad unter vermindertem Druck;

DOI:10.1002/ardp.19322700608

Reference yield:

(3,4-dimethoxy-phenyl)-thioacetic acid methylamide (157370-07-5) → 6,7-dimethoxy-2-methyl-3,4-dihydro-isoquinolinium; chloride (553-28-6)

Guidance literature:

Multi-step reaction with 2 steps

1: aq.-ethanolic hydrochloric acid / an Blei-Elektroden

2: 210 °C / Erwaermen des Reaktionsprodukts in Benzol mit Thionylchlorid und Erhitzen des erhaltenen kristallinen Reaktionsprodukts auf 140grad unter vermindertem Druck

With hydrogenchloride;

DOI:10.1002/ardp.19322700608

Reference yield:

2-(3,4-dimethoxyphenyl)-ethylamine (120-20-7) → 6,7-dimethoxy-2-methyl-3,4-dihydro-isoquinolinium; chloride (553-28-6)

Guidance literature:

Multi-step reaction with 2 steps

1: benzene / und Erwaermen des Reaktionsprodukts mit wss.Aethanol

2: 210 °C / Erwaermen des Reaktionsprodukts in Benzol mit Thionylchlorid und Erhitzen des erhaltenen kristallinen Reaktionsprodukts auf 140grad unter vermindertem Druck

With benzene;

DOI:10.1002/ardp.19322700608

upstream raw materials:

N-methylhomoveratrylamine

formic acid

6,7-dimethoxy-3,4-dihydro-isoquinoline

methylene chloride

Downstream raw materials:

deoxyepinephrine