Technology Process of Carbamic acid,
[2-[[4-[(3,5-dimethylphenyl)methyl]-5-ethyl-1,2-dihydro-6-methyl-2-oxo-3-
pyridinyl]amino]-2-oxoethyl]-, 1,1-dimethylethyl ester
There total 7 articles about Carbamic acid,
[2-[[4-[(3,5-dimethylphenyl)methyl]-5-ethyl-1,2-dihydro-6-methyl-2-oxo-3-
pyridinyl]amino]-2-oxoethyl]-, 1,1-dimethylethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
BOC-glycine;
With
benzotriazol-1-ol; dicyclohexyl-carbodiimide;
In
dichloromethane;
at 0 ℃;
for 0.5h;
3-amino-4-(3,5-dimethylbenzyl)-5-ethyl-6-methylpyridin-2(1H)-one;
With
4-methyl-morpholine;
In
dichloromethane;
at 20 ℃;
for 3.5h;
Further stages.;
DOI:10.1021/jm0009437
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: n-BuLi; TMEDA / tetrahydrofuran; hexane / 1 h / 0 °C
1.2: CuII dimethylsulfide complex / tetrahydrofuran; hexane / 0.5 h / 0 °C
1.3: 37 percent / tetrahydrofuran; hexane / 12 h / 20 °C
2.1: 100 percent / aq. HCl / 3.5 h / Heating
3.1: DCC; HOBt / CH2Cl2 / 0.5 h / 0 °C
3.2: 70.5 percent / N-methylmorpholine / CH2Cl2 / 3.5 h / 20 °C
With
hydrogenchloride; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; benzotriazol-1-ol; dicyclohexyl-carbodiimide;
In
tetrahydrofuran; hexane; dichloromethane;
1.1: Metallation / 1.2: complexation / 1.3: Alkylation / 2.1: Hydrolysis / 3.1: Condensation / 3.2: Acylation;
DOI:10.1021/jm0009437
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: n-BuLi; TMEDA / tetrahydrofuran; hexane / 1 h / 0 °C
1.2: 71 percent / tetrahydrofuran / 12 h / 20 °C
2.1: 95 percent / pyridine / 84 h / 60 °C
3.1: 99 percent / H2; AcOH / 30percent Pd/C / H2O; dioxane / 24 h / 20 °C / 7600.51 Torr
4.1: 100 percent / aq. HCl / 3.5 h / Heating
5.1: DCC; HOBt / CH2Cl2 / 0.5 h / 0 °C
5.2: 70.5 percent / N-methylmorpholine / CH2Cl2 / 3.5 h / 20 °C
With
pyridine; hydrogenchloride; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; hydrogen; benzotriazol-1-ol; acetic acid; dicyclohexyl-carbodiimide;
30percent Pd/C;
In
tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; water;
1.1: Metallation / 1.2: Addition / 2.1: Acetylation / 3.1: Catalytic hydrogenation / 4.1: Hydrolysis / 5.1: Condensation / 5.2: Acylation;
DOI:10.1021/jm0009437
