Sunifiram

Base Information

Chemical Name:Sunifiram
CAS No.:314728-85-3
Molecular Formula:C14H18N2O2
Molecular Weight:246.30
Hs Code.:
UNII:66924E735K
ChEMBL ID:CHEMBL309176
DSSTox Substance ID:DTXSID10400996
Nikkaji Number:J1.445.767D
Wikidata:Q6590525
Wikipedia:Sunifiram
Mol file:314728-85-3.mol

Synonyms:DM 235;DM-235;DM235 cpd;sunifiram

Suppliers and Price of Sunifiram

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Sunifiram
5g
$ 525.00

DC Chemicals
Sunifiram >98%
1 g
$ 1200.00

Crysdot
Sunifiram 98+%
5mg
$ 40.00

Crysdot
Sunifiram 98+%
10mg
$ 63.00

ChemScene
Sunifiram 99.88%
10mg
$ 108.00

ChemScene
Sunifiram 99.88%
5mg
$ 60.00

American Custom Chemicals Corporation
DM 235 95.00%
5MG
$ 178.20

American Custom Chemicals Corporation
DM 235 95.00%
25MG
$ 764.64

Ambeed
1-(4-Benzoylpiperazin-1-yl)propan-1-one 98+%
25g
$ 62.00

Ambeed
1-(4-Benzoylpiperazin-1-yl)propan-1-one 98+%
5g
$ 19.00

Total 157 raw suppliers

Chemical Property of Sunifiram

Chemical Property:

Boiling Point:442.0±38.0 °C(Predicted)
PKA:0.08±0.70(Predicted)
PSA：40.62000
Density:1.154±0.06 g/cm3 (20 oC 760 Torr), Calc.*
LogP:1.25680
Storage Temp.:2-8°C
Solubility.:H2O: soluble24mg/mL
XLogP3:1.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:246.136827821
Heavy Atom Count:18
Complexity:303

Purity/Quality:

99%, ^*data from raw suppliers

Sunifiram ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC(=O)N1CCN(CC1)C(=O)C2=CC=CC=C2
Description Sunifiram (DM-235) is a synthetic derivative of piracetam, although due to breaking the pyrrolidone backbone it is no longer in the racetam class of drugs (yet by being derived from them, it is still commonly associated with this class).Sunifiram has mechanisms similar to nefiracetam in the hippocampus, and similar to that drug sunifiram shows anti-amnesiac properties and is potentially a cognitive enhancer. Its anti-amnesiac activity is several orders of magnitude greater than piracetam on a per weight basis, and preliminary evidence suggest it has a similarly low toxicity profile.
Uses Sunifiram is a potent nootropic agent.

Technology Process of Sunifiram

There total 4 articles about Sunifiram which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 54264-50-5
1-(1H-benzo[d][1,2,3]triazol-1-yl)propan-1-one

: 13754-38-6
N-Benzoylpiperazine

: 314728-85-3
Sunifiram

Guidance literature:: In butan-1-ol; at 60 ℃;
DOI:10.1080/14756366.2022.2068147

Reference yield: 87.0%

: 79-03-8
propionyl chloride

: 13754-38-6
N-Benzoylpiperazine

: 314728-85-3
Sunifiram

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 4h; Inert atmosphere;
DOI:10.1021/jacs.9b03138

Reference yield:

: 314728-80-8
1-(4-benzyl-piperazin-1-yl)-propan-1-one

: 314728-85-3
Sunifiram

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / H₂ / 10percent Pd/C / ethanol / 12 h / 2430.66 Torr

2: NEt₃ / acetonitrile / 2 h / 20 °C

With hydrogen; triethylamine; 10percent Pd/C; In ethanol; acetonitrile;
DOI:10.1021/jm000972h