Idremcinal

Base Information

• Chemical Name: Idremcinal
• CAS No.: 110480-13-2
• Molecular Formula: C₃₉H₆₉NO₁₂
• Molecular Weight: 743.976
• Mol file: 110480-13-2.mol

Synonyms:6,15-Dioxabicyclo[10.2.1]pentadecane,erythromycin deriv.; EM 574; Idremcinal

Chemical Property of Idremcinal

Chemical Property:

• Vapor Pressure: 6.53E-30mmHg at 25°C
• Boiling Point: 804°Cat760mmHg
• Flash Point: 440.1°C
• PSA: 165.84000
• Density: 1.18g/cm³
• LogP: 3.67090

Purity/Quality:

98% ^*data from raw suppliers

EM574 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Gastrointestinal prokinetic (motilin agonist). EM574 is an erythromycin derivative that is a motilin receptor antagonist.

Technology Process of Idremcinal

There total 2 articles about Idremcinal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

2-iodo-propane (75-30-9) + de(N-methyl)-8,9-anhydroerythromycin A 6,9-hemiacetal (98641-05-5) → Idremcinal (110480-13-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In methanol; at 50 ℃; for 22h;

DOI:10.1248/cpb.37.2687

Reference yield:

N-Demethylerythromycin A (992-62-1) → Idremcinal (110480-13-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / acetic acid / 1 h / Ambient temperature

2: 27 percent / N,N-diisopropylethylamine / methanol / 22 h / 50 °C

With N-ethyl-N,N-diisopropylamine; In methanol; acetic acid;

DOI:10.1248/cpb.37.2687

upstream raw materials:

2-iodo-propane

de(N-methyl)-8,9-anhydroerythromycin A 6,9-hemiacetal

N-Demethylerythromycin A

Refernces