4-(trifluoroMethyl)-1h-indole-2-carboxylic acid

Base Information

Chemical Name:4-(trifluoroMethyl)-1h-indole-2-carboxylic acid
CAS No.:317-59-9
Molecular Formula:C10H6F3NO2
Molecular Weight:229.15500
Hs Code.:2933990090
Mol file:317-59-9.mol

Synonyms:4-Trifluormethyl-indol-2-carbonsaeure;4-trifluoromethyl-indole-2-carboxylic acid;4-Trifluormethyl-chinaldonitril;4-trifluoromethyl-quinoline-2-carbonitrile;

Suppliers and Price of 4-(trifluoroMethyl)-1h-indole-2-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
4-(TRIFLUOROMETHYL)-1H-INDOLE-2-CARBOXYLIC ACID 95.00%
5MG
$ 496.58

Total 12 raw suppliers

Chemical Property of 4-(trifluoroMethyl)-1h-indole-2-carboxylic acid

Chemical Property:

Melting Point:219.4-220.4 °C
Boiling Point:402.5±40.0 °C(Predicted)
PKA:4.10±0.30(Predicted)
PSA：53.09000
Density:1.549±0.06 g/cm3(Predicted)
LogP:2.88490

Purity/Quality:

97% ^*data from raw suppliers

4-(TRIFLUOROMETHYL)-1H-INDOLE-2-CARBOXYLIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-(trifluoroMethyl)-1h-indole-2-carboxylic acid

There total 4 articles about 4-(trifluoroMethyl)-1h-indole-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1098340-27-2
methyl 4-trifluoromethyl-1H-indole-2-carboxylate

: 317-59-9
4-(trifluoromethyl)-1H-indole-2-carboxylic acid

Guidance literature:: With water monomer; lithium hydroxide monohydrate; In tetrahydrofuran; at 20 ℃; for 4h;

Reference yield:

: 317-60-2
4-trifluoromethyl-indole-2-carboxylic acid ethyl ester

: 317-59-9
4-(trifluoromethyl)-1H-indole-2-carboxylic acid

Guidance literature:: With potassium hydroxide;
DOI:10.1021/ja01564a058

Reference yield:

: 1362860-87-4
methyl 2-azido-3-(2-(trifluoromethyl)phenyl)acrylate

: 317-59-9
4-(trifluoromethyl)-1H-indole-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 5,5-dimethyl-1,3-cyclohexadiene / 2 h / 120 °C

2: lithium hydroxide monohydrate; water monomer / tetrahydrofuran / 4 h / 20 °C

With water monomer; lithium hydroxide monohydrate; In tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene;