N-Benzyl-4-piperidinecarboxamide hydrochloride

Base Information

• Chemical Name: N-Benzyl-4-piperidinecarboxamide hydrochloride
• CAS No.: 320420-00-6
• Molecular Formula: C13H18N2O.ClH
• Molecular Weight: 254.76
• Mol file: 320420-00-6.mol

Synonyms:N-benzylpiperidine-4-carboxamide hydrochloride;piperidine-4-carboxylic acid benzylamide hydrochloride;

Chemical Property of N-Benzyl-4-piperidinecarboxamide hydrochloride

Chemical Property:

• Melting Point: 79-83 °C
• PSA: 41.13000
• LogP: 2.82410
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

N-Benzylpiperidine-4-carboxamidehydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Benzyl-4-piperidinecarboxamide hydrochloride

There total 3 articles about N-Benzyl-4-piperidinecarboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-(tert-butoxycarbonyl)-4-(4-phenylmethyl-amidoacetyl)piperidine (188527-08-4) → N-(phenylmethyl)-4-piperidinecarboxamide hydrochloride (320420-00-6)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; 1,4-dioxane; at 20 ℃; for 1h;

Reference yield: 98.0%

isonicotinic acid benzylamide (6320-63-4) → N-(phenylmethyl)-4-piperidinecarboxamide hydrochloride (320420-00-6)

Guidance literature:

With 1,1,2-trichloroethane; palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 9h; under 760.051 Torr;

DOI:10.1016/j.tet.2009.08.011

Reference yield:

N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid (84358-13-4,174286-31-8) → N-(phenylmethyl)-4-piperidinecarboxamide hydrochloride (320420-00-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0.33 h

2: hydrogenchloride / 1,4-dioxane; tetrahydrofuran / 1 h / 20 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane;

upstream raw materials:

N-(tert-butoxycarbonyl)-4-(4-phenylmethyl-amidoacetyl)piperidine

isonicotinic acid benzylamide

N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid

Downstream raw materials:

1-(2-hydroxy-ethyl)-piperidine-4-carboxylic acid benzylamide

1-(3-cyano-3,3-diphenyl-propyl)-piperidine-4-carboxylic acid benzylamide

N-benzyl-1-(1-(4-chlorobenzyl)-1H-imidazole-2-carbonyl)piperidine-4-carboxamide