tert-butyl (6-(trifluoromethyl)pyridin-3-yl)carbamate

Base Information

Chemical Name:tert-butyl (6-(trifluoromethyl)pyridin-3-yl)carbamate
CAS No.:325457-86-1
Molecular Formula:C₁₁H₁₃F₃N₂O₂
Molecular Weight:262.232
Hs Code.:
Mol file:325457-86-1.mol

Synonyms:tert-butyl (6-trifluoromethylpyridin-3-yl)carbamate;(6-trifluoromethylpyridin-3-yl) carbamic acid tert-butyl ester;

Suppliers and Price of tert-butyl (6-(trifluoromethyl)pyridin-3-yl)carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Chemcia Scientific
(6-Trifluoromethyl-pyridin-3-yl)-carbamicacidtert-butylester 95%
0.5 G
$ 225.00

Advanced Chemicals Intermediatesced Chemicals Intermediates
(6-Trifluoromethyl-pyridin-3-yl)-carbamicacidtert-butylester 95%+
5g
$ 978.75

Total 1 raw suppliers

Chemical Property of tert-butyl (6-(trifluoromethyl)pyridin-3-yl)carbamate

Chemical Property:

Melting Point:117 °C
PSA：51.22000
LogP:3.52040

Purity/Quality:: (6-Trifluoromethyl-pyridin-3-yl)-carbamicacidtert-butylester 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl (6-(trifluoromethyl)pyridin-3-yl)carbamate

There total 2 articles about tert-butyl (6-(trifluoromethyl)pyridin-3-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 106877-33-2
6-(trifluoromethyl)pyridin-3-amine

: 325457-86-1
tert-butyl (6-(trifluoromethyl)pyridin-3-yl)carbamate

Guidance literature:: In 1,4-dioxane; for 67h; Reflux;

Reference yield: 66.0%

: 75-65-0
tert-butyl alcohol

: 231291-22-8
6-trifluoromethylnicotinic acid

: 325457-86-1
tert-butyl (6-(trifluoromethyl)pyridin-3-yl)carbamate

Guidance literature:: With diphenylphosphoryl azide; triethylamine; for 5h; Heating / reflux;

Reference yield:

: 325457-86-1
tert-butyl (6-(trifluoromethyl)pyridin-3-yl)carbamate

: N-(6-trifluoromethylthiazolo[4,5-c]pyridine-2-yl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

1.2: 1.25 h / -78 - -10 °C / Inert atmosphere

1.3: -78 - 20 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 24 h / 21 °C

3.1: acetone / 48 h / 56 °C

With N,N,N,N,-tetramethylethylenediamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; acetone;