Methanesulfonic acid, trifluoro-, 3-aminophenyl ester

Base Information

• Chemical Name: Methanesulfonic acid, trifluoro-, 3-aminophenyl ester
• CAS No.: 32578-28-2
• Molecular Formula: C7H6F3NO3S
• Molecular Weight: 241.191
• Mol file: 32578-28-2.mol

Synonyms:Methanesulfonic acid,trifluoro-,3-aminophenyl ester;

Chemical Property of Methanesulfonic acid, trifluoro-, 3-aminophenyl ester

Chemical Property:

• Boiling Point: 315.2±42.0 °C(Predicted)
• PSA: 77.77000
• Density: 1.574±0.06 g/cm3(Predicted)
• LogP: 3.15920

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methanesulfonic acid, trifluoro-, 3-aminophenyl ester

There total 6 articles about Methanesulfonic acid, trifluoro-, 3-aminophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

N,N-phenylbistrifluoromethane-sulfonimide (37595-74-7) + m-Hydroxyaniline (591-27-5) → (3-Aminophenyl)-trifluormethansulfonat (32578-28-2)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/acs.joc.1c02251

Reference yield: 67.0%

Trifluoromethanesulfonyl fluoride (335-05-7) + 3-((trimethylsilyl)oxy)aniline (36309-43-0) → trimethylsilyl fluoride (420-56-4) + (3-Aminophenyl)-trifluormethansulfonat (32578-28-2)

Guidance literature:

triethylamine; In neat (no solvent); in presence of a few HF, CsF, KF, (R4N)F, (C2H5)2NH, effectless in presence of pyridinp, NaF and NH4F;

Reference yield:

Trifluoromethanesulfonyl fluoride (335-05-7) + m-Hydroxyaniline (591-27-5) → (3-Aminophenyl)-trifluormethansulfonat (32578-28-2)

Guidance literature:

In acetone; in presence of (C2H5)3N, 20°C, 1 h, under N2 atmosphere;

upstream raw materials:

Trifluoromethanesulfonyl fluoride

3-((trimethylsilyl)oxy)aniline

m-Hydroxyaniline

N,N-phenylbistrifluoromethane-sulfonimide