Fluorotrimethylsilane

Base Information

• Chemical Name: Fluorotrimethylsilane
• CAS No.: 420-56-4
• Molecular Formula: C3H9FSi
• Molecular Weight: 92.1884
• Hs Code.: 2931900090
• European Community (EC) Number: 206-997-0
• DSSTox Substance ID: DTXSID5059959
• Nikkaji Number: J102.055B
• Wikidata: Q64483861
• Mol file: 420-56-4.mol

Synonyms:fluorotrimethylsilane;trimethylfluorosilane

Chemical Property of Fluorotrimethylsilane

Chemical Property:

• Appearance/Colour: Clear liquid
• Vapor Pressure: 1040mmHg at 25°C
• Melting Point: -74 °C(lit.)
• Refractive Index: 1.337
• Boiling Point: 16 °C at 760 mmHg
• Flash Point: ?22 °F
• PSA: 0.00000
• Density: 0.773 g/cm³
• LogP: 1.79080
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 92.04575498
• Heavy Atom Count: 5
• Complexity: 28.4

Purity/Quality:

98%,99%, ^*data from raw suppliers

Trimethylfluorosilane 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F+,F,Xi
• Hazard Codes: F+,Xi,F
• Statements: 12-36/37/38
• Safety Statements: 9-16-26-33

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Toxic Gases & Vapors -> Fluorosilanes
• Canonical SMILES: C[Si](C)(C)F
• Uses: Trimethylfluorosilane is used in the pharmaceutical and chemical industry.

Technology Process of Fluorotrimethylsilane

There total 488 articles about Fluorotrimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-phenyl-1-trimethylsilyloxyethane (14856-75-8) → trimethylsilyl fluoride (420-56-4) + 1-Phenylethanol (98-85-1,13323-81-4)

Guidance literature:

With methylammmonium fluoride; In methanol; at 20 ℃; for 0.5h; further solvents (CH₃CN/THF);

Reference yield: 96.0%

[2-(2-[1,3]Dithian-2-yl-1-methyl-ethoxymethoxy)-ethyl]-trimethyl-silane (76513-61-6) → formaldehyd (50-00-0,30525-89-4,61233-19-0) + ethene (74-85-1) + trimethylsilyl fluoride (420-56-4) + rac-1-(1,3-dithian-2-yl)-2-propanol (14950-49-3)

Guidance literature:

With tetrabutyl ammonium fluoride; In N,N,N,N,N,N-hexamethylphosphoric triamide; at 45 ℃; for 5h;

DOI:10.1016/S0040-4039(00)78684-9

Reference yield: 92.0%

Trimethyl-[2-((3aR,5aS,8aS,8bR)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-3a-ylmethoxymethoxy)-ethyl]-silane (76513-67-2) → formaldehyd (50-00-0,30525-89-4,61233-19-0) + ethene (74-85-1) + trimethylsilyl fluoride (420-56-4) + 2,3:4,5-di-O-isopropylidene-β-L-fructopyranose (20880-92-6,22164-03-0,76549-77-4,132620-61-2,133907-41-2,76513-58-1)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 45 ℃; for 12h;

DOI:10.1016/S0040-4039(00)78684-9

upstream raw materials:

chloro-trimethyl-silane

1,1-difluoro-10-methyl-3,3,7,7-tetrakis(trifluoromethyl)-4,6-benzo-1-ioda-2,8-dioxabicyclo<3.3.1>octane

trimethylsilyl trifluoroacetate

aluminium trichloride

Downstream raw materials:

Trimethylsilanol

Trimethylmethoxysilane

dimethyldifluorosilane

N,N-Dimethyltrimethylsilylamine

Refernces

• 1、 Sprenger,Cowley. "". . p. 333,337,340,341,342. Retrieved 1976.
• 2、 Cybulski, Mateusz K.,Davies, Caroline J. E.,Lowe, John P.,Mahon, Mary F.,Whittlesey, Michael K.. "C-F Bond Activation of P(C6F5)3 by Ruthenium Dihydride Complexes: Isolation and Reactivity of the missing Ru(PPh3)3H(halide) Complex, Ru(PPh3)3HF". . p. 13749 - 13760. Retrieved 2018.
• 3、 Romer,Brauman. "Electron photodetachment spectroscopy of (E)- and (Z)-propionaldehyde enolate anions. Electron affinities of the stereoisomers of propionaldehyde enolate radicals". . p. 2054 - 2055. Retrieved 1997.
• 4、 Della, Ernest W.,Tsanaktsidis, John. "A Convenient Synthesis of Trimethylsilyl Fluoride". . p. 407. Retrieved 1988.
• 5、 Wight, Charles A.,Beauchamp, J. L.. "Infrared Laser Photodetachment of Electrons from Vibrationally Excited Allyl Anions". . p. 4426 - 4430. Retrieved 1984.
• 6、 Lange, Horst,Naumann, Dieter. "(CF3)2Cd*D UND (CF3)2Zn*D: NEUE REAGENZIEN FUER DIFLUORCARBEN-REAKTIONEN". . p. 299 - 308. Retrieved 1985.
• 7、 Cartlidge, Ashleigh J.,Matthews, Peter D.. "Indium(III) promoted oxidative P-P coupling of silylphosphines". supporting information. . Retrieved 2022/01/28.
• 8、 -. "A NEW METHOD OF 18F LABELLING AND INTERMEDIATE SALTS". Page/Page column 37. . Retrieved 2021/06/26.