1,4-Dibenzylpiperazin-2-one

Base Information

Chemical Name:1,4-Dibenzylpiperazin-2-one
CAS No.:32705-80-9
Molecular Formula:C18H20N2O
Molecular Weight:280.37
Hs Code.:
DSSTox Substance ID:DTXSID40541149
Nikkaji Number:J503.932K
Wikidata:Q82417402

Synonyms:1,4-dibenzyl-2-piperazinone;1,4-Dibenzylpiperazin-2-one;32705-80-9;SCHEMBL10841960;DTXSID40541149

Suppliers and Price of 1,4-Dibenzylpiperazin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1,4-Dibenzylpiperazin-2-one

Chemical Property:

XLogP3:2.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:280.157563266
Heavy Atom Count:21
Complexity:332

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CN(C(=O)CN1CC2=CC=CC=C2)CC3=CC=CC=C3

Technology Process of 1,4-Dibenzylpiperazin-2-one

There total 5 articles about 1,4-Dibenzylpiperazin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 100-46-9
benzylamine

: 301541-32-2
2-chloro-N-(2-oxoethyl)-N-(phenylmethyl)acetamide

: 32705-80-9
1,4-dibenzylpiperazin-2-one

: N-benzyl-N-(2-benzylamino-ethyl)-2-chloro-acetamide

Guidance literature:: With 4 A molecular sieve; sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃;
DOI:10.1016/S0040-4039(00)01063-7

Reference yield:

: 105-39-5
chloroacetic acid ethyl ester

: 140-28-3,87170-83-0
N,N'-Dibenzylethylenediamine

: 32705-80-9
1,4-dibenzylpiperazin-2-one

Guidance literature:: at 135 ℃;
DOI:10.1021/ja01165a532

Reference yield:

: 100129-49-5
N-benzyl-2-chloro-N-(2-hydroxyethyl)acetamide

: 32705-80-9
1,4-dibenzylpiperazin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / DMSO; (COCl)2; Et₃N / CH₂Cl₂ / 0.75 h / -78 - 20 °C

2: 70 percent / 4 Angstroem molecular sieves; sodium triacetoxyborohydride / 1,2-dichloro-ethane / 20 °C

With oxalyl dichloride; 4 A molecular sieve; sodium tris(acetoxy)borohydride; dimethyl sulfoxide; triethylamine; In dichloromethane; 1,2-dichloro-ethane; 1: Oxidation / 2: Cyclization;
DOI:10.1016/S0040-4039(00)01063-7