6-amino-6-deoxyfumagillol

Base Information

• Chemical Name: 6-amino-6-deoxyfumagillol
• CAS No.: 132746-71-5
• Molecular Formula: C₁₆H₂₇NO₃
• Molecular Weight: 281.395
• Mol file: 132746-71-5.mol

Synonyms:1-Oxaspiro[2.5]octan-6-amine,5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-, (3R,4S,5S,6R)-(9CI); 1-Oxaspiro[2.5]octan-6-amine,5-methoxy-4-[2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-, [3R-[3a,4a(2R*,3R*),5b,6b]]-

Chemical Property of 6-amino-6-deoxyfumagillol

Chemical Property:

• Vapor Pressure: 7.13E-06mmHg at 25°C
• Boiling Point: 376.7°Cat760mmHg
• Flash Point: 179.2°C
• PSA: 60.31000
• Density: 1.1g/cm³
• LogP: 2.72180

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-amino-6-deoxyfumagillol

There total 2 articles about 6-amino-6-deoxyfumagillol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

Fumaginone (132746-88-4) → 6-amino-6-deoxyfumagillol (132746-71-5)

Guidance literature:

With ammonium acetate; sodium cyanoborohydride; In methanol; for 1h;

DOI:10.1248/cpb.40.575

Reference yield:

fumagillol (35903-52-7,128656-25-7,132746-73-7,108102-51-8) → 6-amino-6-deoxyfumagillol (132746-71-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / CrO₃*pyridine / CH₂Cl₂ / 1 h / Ambient temperature

2: 40 percent / NaBH₃CN, AcONH₄ / methanol / 1 h

With chromium trioxide-pyridine complex; ammonium acetate; sodium cyanoborohydride; In methanol; dichloromethane;

DOI:10.1248/cpb.40.575

Reference yield:

benzoyl chloride (98-88-4) + 6-amino-6-deoxyfumagillol (132746-71-5) → 6-benzoylamino-6-deoxyfumagillol (132658-33-4)

Guidance literature:

With sodium hydrogencarbonate; In chloroform; for 0.5h; Yield given;

DOI:10.1248/cpb.40.575

upstream raw materials:

Fumaginone

fumagillol

Downstream raw materials:

6-benzoylamino-6-deoxyfumagillol

6-toluenesulfonylamino-6-deoxyfumagillol

Refernces