4-Amino-2-hydroxy-6-methylpyridine

Base Information

• Chemical Name: 4-Amino-2-hydroxy-6-methylpyridine
• CAS No.: 33259-25-5
• Molecular Formula: C6H8N2O
• Molecular Weight: 124.142
• DSSTox Substance ID: DTXSID80434788
• Wikidata: Q82249298
• Mol file: 33259-25-5.mol

Synonyms:33259-25-5;4-Amino-6-methylpyridin-2-ol;4-Amino-2-hydroxy-6-methylpyridine;4-amino-6-methyl-1H-pyridin-2-one;4-amino-6-methylpyridin-2(1H)-one;1823772-69-5;4-amino-6-methyl-2-pyridone;SCHEMBL2884356;SCHEMBL19327477;DTXSID80434788;YSHIXXHBMJEWGK-UHFFFAOYSA-N;MFCD12546374;4-amino-6-methyl-2(1H)-pyridinone;AKOS006338591;AT32529;SB53246;4-Amino-6-methyl-2(1H)-pyridinone, 99%;FT-0725558;A929259

Chemical Property of 4-Amino-2-hydroxy-6-methylpyridine

Chemical Property:

• PSA: 59.14000
• LogP: 1.25900
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: -0.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 124.063662883
• Heavy Atom Count: 9
• Complexity: 203

Purity/Quality:

97% ^*data from raw suppliers

4-Amino-6-methylpyridin-2-ol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=CC(=O)N1)N

Technology Process of 4-Amino-2-hydroxy-6-methylpyridine

There total 4 articles about 4-Amino-2-hydroxy-6-methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

methyl-6 benzylamino-4 pyridone (61190-99-6) → 4-amino-6-methylpyridine-2(1H)-one (33259-25-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In acetic acid; Ambient temperature;

Reference yield:

4-hydroxy-6-methyl-2-pyridone (3749-51-7,4664-15-7) → 4-amino-6-methylpyridine-2(1H)-one (33259-25-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / 1.) reflux, 72 h, 2.) r.t., 12 h

2: 85 percent / H₂ / Pd-C / acetic acid / Ambient temperature

With hydrogen; palladium on activated charcoal; In acetic acid;

Reference yield:

ethyl aminocrotonate (626-34-6,7318-00-5,41867-20-3) → 4-amino-6-methyl-pyridin-2-ol (33259-25-5)

Guidance literature:

durch Destillation und anschl. Behandeln mit Aceton;

upstream raw materials:

methyl-6 benzylamino-4 pyridone

4-hydroxy-6-methyl-2-pyridone

ethyl aminocrotonate

Downstream raw materials:

2-cyanoethyl 4-(4-cyano-2-methoxyphenyl)-2,7-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate

4-(4-cyano-2-methoxyphenyl)-2,7-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carbonitrile

α-picoline