1H-Pyrrole-3-propanoic acid, 5-[[5-[(1,1-dimethylethoxy)carbonyl]-3-ethyl-4-methyl-1H-pyrrol-2-yl]meth yl]-4-methyl-2-[(phenylmethoxy)carbonyl]-, methyl ester

Base Information

Chemical Name:1H-Pyrrole-3-propanoic acid, 5-[[5-[(1,1-dimethylethoxy)carbonyl]-3-ethyl-4-methyl-1H-pyrrol-2-yl]meth yl]-4-methyl-2-[(phenylmethoxy)carbonyl]-, methyl ester
CAS No.:33317-09-8
Molecular Formula:C30H38N2O6
Molecular Weight:522.642
Hs Code.:

1H-Pyrrole-3-propanoic acid,
5-[[5-[(1,1-dimethylethoxy)carbonyl]-3-ethyl-4-methyl-1H-pyrrol-2-yl]meth
yl]-4-methyl-2-[(phenylmethoxy)carbonyl]-, methyl ester

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Chemical Property of 1H-Pyrrole-3-propanoic acid, 5-[[5-[(1,1-dimethylethoxy)carbonyl]-3-ethyl-4-methyl-1H-pyrrol-2-yl]meth yl]-4-methyl-2-[(phenylmethoxy)carbonyl]-, methyl ester

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MSDS Files:: SDS file from LookChem

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Technology Process of 1H-Pyrrole-3-propanoic acid, 5-[[5-[(1,1-dimethylethoxy)carbonyl]-3-ethyl-4-methyl-1H-pyrrol-2-yl]meth yl]-4-methyl-2-[(phenylmethoxy)carbonyl]-, methyl ester

There total 8 articles about 1H-Pyrrole-3-propanoic acid, 5-[[5-[(1,1-dimethylethoxy)carbonyl]-3-ethyl-4-methyl-1H-pyrrol-2-yl]meth yl]-4-methyl-2-[(phenylmethoxy)carbonyl]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.5%

: 51671-81-9
2-benzoyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-methyl-5-(acetoxymethyl)pyrrole

: 75488-15-2
tert-butyl 4-ethyl-3-methyl-1H-pyrrole-2-carboxylate

: 33317-09-8
benzyl 5'-t-butoxycarbonyl-3'-ethyl-4-(2-methoxycarbonylethyl)-3,4'-dimethylpyrromethane-5-carboxylate

Guidance literature:: With toluene-4-sulfonic acid; In acetic acid; at 45 ℃; for 4h;
DOI:10.1016/S0040-4020(01)91126-3

Reference yield:

: 967-38-4
2-(benzyloxycarbonyl)-4-ethyl-3-methylpyrrole-5-carboxylic acid

: 33317-09-8
benzyl 5'-t-butoxycarbonyl-3'-ethyl-4-(2-methoxycarbonylethyl)-3,4'-dimethylpyrromethane-5-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / H₂, triethylamine / 10percent Pd on charcoal / tetrahydrofuran / 3 h / 2585.7 Torr

2: 54 percent / dicyclohexylcarbodiimide / tetrahydrofuran / 18 h / 20 °C

3: 50 percent / p-toluensulfonic acid / CH₂Cl₂ / 4 h / 40 °C

With hydrogen; toluene-4-sulfonic acid; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4020(01)87636-5

Reference yield:

: 31896-92-1
4-ethyl-3,5-dimethyl-pyrrole-2-carboxylic acid tert-butyl ester

: 33317-09-8
benzyl 5'-t-butoxycarbonyl-3'-ethyl-4-(2-methoxycarbonylethyl)-3,4'-dimethylpyrromethane-5-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 1) sulfuryl chloride; 2) sodium acetate / 1) CCl₄, 3h, room temperature; 2) dioxan/water, reflux, 2h, room temperature

2: 78.1 percent / sodium bicarbonate, iodine, potassium iodide / methanol / 60 °C

3: 99 percent / sodium acetate, H₂ / Adams catalyst / methanol / 760 Torr / Ambient temperature

4: 77.5 percent / p-toluene sulfonic acid hydrate / acetic acid / 4 h / 45 °C

With sulfuryl dichloride; hydrogen; iodine; sodium acetate; sodium hydrogencarbonate; toluene-4-sulfonic acid; potassium iodide; platinum(IV) oxide; In methanol; acetic acid;
DOI:10.1016/S0040-4020(01)91126-3